Evidence map›Paper›PMID 34431087›Full record

ArticleImmunology2022

Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3

Farhan Basit, Tom van Oorschot, Jessie van Buggenum, Rico J E Derks, Sarantos Kostidis, Martin Giera, I Jolanda M de Vries

Open access · hybridAbstract read
In one paragraph

Article in Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Facts and Hopes in Using Omics to Advance Combined Immunotherapy Strategies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  6. Review
  7. iScience · 2023
    Article
  8. Lipid metabolism in dendritic cell biology.Immunological reviews · 2023
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Farhan BasitDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.ORCID 0000-0001-8205-8393
Tom van OorschotDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.
Jessie van BuggenumDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.
Rico J E DerksCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Sarantos KostidisCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
Martin GieraCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.
I Jolanda M de VriesDepartment of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) bridge the connection between innate and adaptive immunity. DCs present antigens to T cells and stimulate potent cytotoxic T-cell responses. Metabolic reprogramming is critical for DC development and activation; however, metabolic adaptations and regulation in DC subsets remains largely uncharacterized. Here, we mapped metabolomic and lipidomic signatures associated with the activation phenotype of human conventional DC type 1, a DC subset specialized in cross-presentation and therefore of major importance for the stimulation of CD8

Indexed as

Lipid MetabolismLipidomicsAmino AcidsBiomarkersCytokinesDendritic CellsHumansImmunophenotypingLipopolysaccharide ReceptorsMetabolic Networks and PathwaysMetabolomeMetabolomicsOxidative PhosphorylationThrombomodulinToll-Like ReceptorsAmino AcidsBiomarkersCytokinesLipopolysaccharide ReceptorsTHBD protein, humanThrombomodulinToll-Like ReceptorsBDCA3dendritic cell activationlipid mediatorsmetabolomics

Identifiers

PMID34431087
PMCPMC9426619
OpenAlexW3196244993

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.