Evidence map›Paper›PMID 34431085›Full record

ArticleBritish journal of haematology2021

Epstein-Barr virus (EBV) deletions as biomarkers of response to treatment of chronic active EBV.

Cristina Venturini, Charlotte J Houldcroft, Arina Lazareva, Fanny Wegner, Sofia Morfopoulou, Persis J Amrolia, Zainab Golwala, Anupama Rao, Stephen D Marks, Jacob Simmonds and 5 more

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. EBV Genome Variations and Association With Diseases.Journal of medical virology · 2026
    Review
  2. Review
  3. Article
  4. Epstein-Barr Virus-Associated T/NK-Cell Neoplasms.Journal of medical virology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 4 countries.

Cristina VenturiniInstitute of Child Health, University College London, London, UK.ORCID 0000-0002-4769-7912
Charlotte J HouldcroftDepartment of Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0002-1833-5285
Arina LazarevaBone Marrow Transplantation Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0002-8902-9146
Fanny WegnerApplied Microbiology Research, Department of Biomedicine, University of Basel, Switzerland.ORCID 0000-0003-4348-5872
Sofia MorfopoulouInstitute of Child Health, University College London, London, UK.ORCID 0000-0001-8181-4548
Persis J AmroliaBone Marrow Transplantation Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0003-0480-3911
Zainab GolwalaGreat Ormond Street Hospital for Children NHS Foundation Trust, UK.ORCID 0000-0002-8465-5746
Anupama RaoGreat Ormond Street Hospital for Children NHS Foundation Trust, UK.ORCID 0000-0001-7959-2229
Stephen D MarksDepartment of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, UK.ORCID 0000-0001-9850-8352
Jacob SimmondsGreat Ormond Street Hospital for Children NHS Foundation Trust, UK.ORCID 0000-0002-1394-4559
Tetsushi YoshikawaDepartment of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.ORCID 0000-0002-2847-7682
Paul J FarrellSection of Virology, Department of Infectious Disease, Imperial College Faculty of Medicine, London, UK.ORCID 0000-0002-6754-9351
Jeffrey I CohenLaboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Austen J WorthDepartment of Immunology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.ORCID 0000-0001-6803-7385
Judith BreuerInstitute of Child Health, University College London, London, UK.ORCID 0000-0001-8246-0534
Great Ormond Street Hospital for Children NHS Foundation Trust · GBUniversity College London · GBFujita Health University · JPGreat Ormond Street Hospital · GBImperial College London · GBNational Institute of Allergy and Infectious Diseases · USUniversity of Basel · CHUniversity of Cambridge · GB

Funding

Medical Research Council MR/S022597/1Wellcome Trust 204870/Z/16/ZWellcome Trust 206478Wellcome Trust 206478/Z/17/Z
6 · The paper itself

Abstract

Chronic active Epstein-Barr virus (CAEBV) disease is a rare condition characterised by persistent EBV infection in previously healthy individuals. Defective EBV genomes were found in East Asian patients with CAEBV. In the present study, we sequenced 14 blood EBV samples from three UK patients with CAEBV, comparing the results with saliva CAEBV samples and other conditions. We observed EBV deletions in blood, some of which may disrupt viral replication, but not saliva in CAEBV. Deletions were lost overtime after successful treatment. These findings are compatible with CAEBV being associated with the evolution and persistence of EBV

Indexed as

AdolescentAsia, EasternBiomarkersCase-Control StudiesChildChild, PreschoolChronic DiseaseDefective VirusesEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansImmunologic FactorsMalePeripheral Blood Stem Cell TransplantationPolymorphism, Single NucleotideBiomarkersImmunologic FactorsRituximabchronic active EBVdefective viral genomeEpstein-Barr virus

Identifiers

PMID34431085
PMCPMC8589012
OpenAlexW3194546467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.