Evidence map›Paper›PMID 34430903›Full record

ReviewArthroscopy, sports medicine, and rehabilitation2021

Cartilage Restoration for Tibiofemoral Bipolar Lesions Results in Promising Failure Rates: A Systematic Review.

Anirudh K Gowd, Alexander E Weimer, Danielle E Rider, Edward C Beck, Avinesh Agarwalla, Lisa K O'Brien, Michael J Alaia, Cristin M Ferguson, Brian R Waterman

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Arthroscopy, sports medicine, and rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Tribomechanical Properties of PVA/NomexGels (Basel, Switzerland) · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Anirudh K GowdWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Alexander E WeimerWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Danielle E RiderWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Edward C BeckWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Avinesh AgarwallaWestchester Medical Center, Valhalla, New York, U.S.A.
Lisa K O'BrienWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Michael J AlaiaNew York University Langone Health, New York, New York, U.S.A.
Cristin M FergusonWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Brian R WatermanWake Forest University Baptist Medical Center, Winston-Salem, North Carolina, U.S.A.
Atrium Health Wake Forest Baptist · USNYU Langone Health · USWestchester Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of the present study is to systematically review the available literature for management of bipolar lesions within the tibiofemoral joint and determine whether tibiofemoral cartilage restoration is an effective treatment modality.

methodsPubMed and MEDLINE databases were queried between 2000 and 2020 using the following keywords: "osteochondral" and "knee" and "microfracture," "autologous chondrocyte implantation (ACI)," or "transplantation." Articles were reviewed for the presence of a bipolar or "kissing" tibiofemoral lesion and reported lesion size, concomitant procedures, failure rates, and time to failure.

resultsAfter screening 1,295 articles, there were 4 articles available for analysis and a total of 152 knees involving the management of bipolar tibiofemoral lesions. Age ranged from 14 to 60 years, and mean follow-up was between 12 and 240 months. There was 1 retrospective cohort study (36 knees) and 3 case series (mean, 38.7 ± 17.5 knees). There were 58 knees treated with bipolar osteochondral allograft (OCA) transplantation, 58 knees treated with bipolar ACI, 20 knees treated with femoral OCA and tibial debridement, and 16 knees treated with femoral OCA and tibial microfracture. There were 37 failures (24.3%): 16 patients (10.5%) were converted to unicompartmental or total knee arthroplasty, 4 restorative procedures (2.6%) were revised, and 8 patients (1.6%) had unsatisfactory outcomes only. The remaining 15 failures (9.9%) had an unspecified combination of objective failure. The mean rate of failure ranged between 0% and 44.1% (

conclusionsCartilage restoration, through both ACI and OCA, had failure rates between 0% and 44% in patients with bipolar lesions of the tibiofemoral compartment. Although a higher level of evidence is required to prove efficacy, the current study demonstrates midterm survivorship rates between 55% and 100%, which may delay the need for secondary arthroplasty. LEVEL OF EVIDENCE: Level IV, systematic review of Level IV studies.

Identifiers

PMID34430903
PMCPMC8365214
OpenAlexW3175438079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.