ArticleiScience2021
BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology.
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In one paragraph
Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Meta-analysis and in-silico functional characterization of the SNCA variant rs356220 in Parkinson's disease.Scientific reports · 2025Pooled it
- Functional Pathological Features and Molecular Markers in Alzheimer's Disease.International journal of molecular sciences · 2026Review
- The Central Role of Neuronal Cell Death in Alzheimer's Disease Pathobiology.Biomedicines · 2026Review
- Decoding the mechanisms of amyloid-β in synaptic toxicity.Journal of Alzheimer's disease : JAD · 2026Review
- De-2-hydroxyisobutyrylation of clusterin modulates neuropathology and memory deficits in an Alzheimer's disease mouse model.Cell communication and signaling : CCS · 2026Article
- Microengineering of the capillary interface of midbrain dopaminergic neurons to study Parkinson's disease vascular alterations.Communications engineering · 2026Article
- The Protective Role of Baicalin in the Regulation of NLRP3 Inflammasome in Different Diseases.Cell biochemistry and biophysics · 2025Review
- The Conceivable Role of Metabolic Syndrome in the Pathogenesis of Alzheimer's Disease: Cellular and Subcellular Alterations in Underpinning a Tale of Two.Neuromolecular medicine · 2025Review
- Mitochondrial dysfunction in Alzheimer's disease: Guiding the path to targeted therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Trace Amine-associated Receptor 1: Role in the Implementation of Neuroprotective Signaling Pathways.International journal of molecular and cellular medicine · 2025Review
- Traditional Chinese Medicine-derived formulations and extracts modulating the PI3K/AKT pathway in Alzheimer's disease.Frontiers in pharmacology · 2025Review
- Oxidative/Nitrosative Stress, Apoptosis, and Redox Signaling: Key Players in Neurodegenerative Diseases.Journal of biochemical and molecular toxicology · 2025Review
- Apoptotic extracellular vesicles: emerging biomarkers for cancer and neurodegenerative disease diagnostics.Frontiers in immunology · 2025Review
- The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer's Disease.Neuromolecular medicine · 2024Review
- Pitavastatin sensitizes the EGFR-TKI associated resistance in lung cancer by inhibiting YAP/AKT/BAD-BCL-2 pathway.Cancer cell international · 2024Article
- Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer's Disease.Cell biochemistry and biophysics · 2024Review
- Comprehension of gut microbiota and microRNAs may contribute to the development of innovative treatment tactics against metabolic disorders and psychiatric disorders.International journal of physiology, pathophysiology and pharmacology · 2024Review
- Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease.Theranostics · 2024Article
- Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice.Nature metabolism · 2023Article
- Apoptosis in Alzheimer's disease: insight into the signaling pathways and therapeutic avenues.Apoptosis : an international journal on programmed cell death · 2023Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Liansheng ZhangThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Yun QianThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Jie LiThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Xuan ZhouKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China.
He XuThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Jie YanThe Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allery & Clinical Immunology, Guangzhou Medical University, Guangzhou, Guangdong 510260, China.
Jialing XiangDepartment of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA.
Xiang YuanThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Beicheng SunDepartment of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China.
Sangram S SisodiaDepartment of Neurobiology, The University of Chicago, Chicago, IL 60637, USA.
Yong-Hui JiangDepartment of Pediatrics and Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA.
Xiaohua CaoKey Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China.
Naihe JingThe State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.
Anning LinInstitute of Modern Biology, Nanjing University, Nanjing 210023, China.
Chinese Academy of Sciences · CNEast China Normal University · CNUniversity of Chicago · USDuke University · USIllinois Institute of Technology · USNanjing Drum Tower Hospital · CNSecond Affiliated Hospital of Guangzhou Medical University · CN
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMolecular and circuitry mechanism underlying autism behaviors in Shank3 mouse modelsR01MH117289 · NIMH · YALE UNIVERSITY · PI JIANG, YONG-HUI · 2019 to 2023
$3.2MEpigenetic Therapy and Prader-Willi SyndromeR01HD088626 · NICHD · YALE UNIVERSITY · PI JIANG, YONG-HUI, JIN, JIAN · 2017 to 2021
$2.8MAnalysis of Shank3 Complete and Temporal and Spatial Specific Knockout MiceR01MH098114 · NIMH · DUKE UNIVERSITY · PI JIANG, YONG-HUI · 2012 to 2016
$2.2MIKK signaling network: TNF cytotoxicity, computational modeling and regulationR35GM122457 · NIGMS · UNIVERSITY OF CHICAGO · PI LIN, ANNING · 2017 to 2019
$1.3MMechanism of IKK Signaling NetworkR01GM103868 · NIGMS · UNIVERSITY OF CHICAGO · PI LIN, ANNING · 2013 to 2016
$1.2MMechanism and Regulation of Baxdelta2 in Colorectal CancerR15CA195526 · NCI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI XIANG, JIALING · 2016 to 2016
$458kNCATS NIH HHS UL1 TR001863NCI NIH HHS R15 CA195526NICHD NIH HHS R01 HD088626NIGMS NIH HHS R01 GM103868NIGMS NIH HHS R35 GM122457NIMH NIH HHS R01 MH098114NIMH NIH HHS R01 MH117289
Abstract
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. However, the underlying molecular mechanism is incompletely understood. Here we report that the pro-apoptotic protein BAD as a key regulator for neuronal apoptosis, neuroinflammation and Aβ clearance in AD. BAD pro-apoptotic activity is significantly increased in neurons of AD patients and 5XFAD mice. Conversely, genetic disruption of
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Molecular biologyMolecular neuroscienceNeuroscience
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