ArticleMayo Clinic proceedings. Innovations, quality & outcomes2021
Association Between Accelerometer-Assessed Physical Activity and Severity of COVID-19 in UK Biobank.
Article in Mayo Clinic proceedings. Innovations, quality & outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Prepandemic Physical Activity and Risk of COVID-19 Diagnosis and Hospitalization in Older Adults.JAMA network open · 2024Trial
- C > U mutations generate immunogenic peptides in SARS-CoV-2.Nature communications · 2025Article
- Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity.BMC public health · 2025Observational
- Objectively Measured Physical Activity Using Wrist-Worn Accelerometers as a Predictor of Incident Alzheimer's Disease in the UK Biobank.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review.Journal of medical Internet research · 2024Article
- The Relationship Between Physical Activity and Non-Modifiable Risk Factors on Alzheimer's Disease and Brain Health Markers: A UK Biobank Study.Journal of Alzheimer's disease : JAD · 2024Review
- Evaluating the prediction performance of objective physical activity measures for incident Parkinson's disease in the UK Biobank.Journal of neurology · 2023Article
- COVID-19: Insights into long-term manifestations and lockdown impacts.Journal of sport and health science · 2023Review
- Effect of replacing television viewing with different intensities of physical activity on COVID-19 mortality risk: Short communication from UK Biobank.Scandinavian journal of public health · 2023Article
- Association of Physical Activity With SARS-CoV-2 Infection and Severe Clinical Outcomes Among Patients in South Korea.JAMA network open · 2023Article
- A phenome-wide investigation of risk factors for severe COVID-19.Journal of medical virology · 2023Article
- Accelerometer-Assessed Physical Activity and Cognitive Performance among European Adults Aged 50+: The Mediating Effects of Social Contacts and Depressive Symptoms.Healthcare (Basel, Switzerland) · 2022Article
- The role of physical activity in the clinical outcomes of people diagnosed with Covid-19: A systematic review.JSAMS plus · 2022Review
- Variability in Physical Inactivity Responses of University Students during COVID-19 Pandemic: A Monitoring of Daily Step Counts Using a Smartphone Application.International journal of environmental research and public health · 2022Article
- Effects of physical activity on the severity of illness and mortality in COVID-19 patients: A systematic review and meta-analysis.Frontiers in physiology · 2022Article
- Clustering Accelerometer Activity Patterns from the UK Biobank Cohort.Sensors (Basel, Switzerland) · 2021Article
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo quantify the association between accelerometer-assessed physical activity and coronavirus disease 2019 (COVID-19) outcomes.
methodsData from 82,253 UK Biobank participants with accelerometer data (measured 2013-2015), complete covariate data, and linked COVID-19 data from March 16, 2020, to March 16, 2021, were included. Two outcomes were investigated: severe COVID-19 (positive test result from in-hospital setting or COVID-19 as primary cause of death) and nonsevere COVID-19 (positive test result from community setting). Logistic regressions were used to assess associations with moderate to vigorous physical activity (MVPA), total activity, and intensity gradient. A higher intensity gradient indicates a higher proportion of vigorous activity.
resultsAverage MVPA was 48.1 (32.7) min/d. Physical activity was associated with lower odds of severe COVID-19 (adjusted odds ratio per standard deviation increase: MVPA, 0.75 [95% CI, 0.67 to 0.85]; total, 0.83 [0.74 to 0.92]; intensity, 0.77 [0.70 to 0.86]), with stronger associations in women (MVPA, 0.63 [0.52 to 0.77]; total, 0.76 [0.64 to 0.90]; intensity, 0.63 [0.53 to 0.74]) than in men (MVPA, 0.84 [0.73 to 0.97]; total, 0.88 [0.77 to 1.01]; intensity, 0.88 [0.77 to 1.00]). In contrast, when mutually adjusted, total activity was associated with higher odds of a nonsevere infection (1.10 [1.04 to 1.16]), whereas the intensity gradient was associated with lower odds (0.91 [0.86 to 0.97]).
conclusionOdds of severe COVID-19 were approximately 25% lower per standard deviation (∼30 min/d) MVPA. A greater proportion of vigorous activity was associated with lower odds of severe and nonsevere infections. The association between total activity and higher odds of a nonsevere infection may be through greater community engagement and thus more exposure to the virus. Results support calls for public health messaging highlighting the potential of MVPA for reducing the odds of severe COVID-19.
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