Evidence map›Paper›PMID 34430677›Full record

ArticleNeurobiology of stress2021

Neural connectome prospectively encodes the risk of post-traumatic stress disorder (PTSD) symptom during the COVID-19 pandemic.

Zhiyi Chen, Pan Feng, Benjamin Becker, Ting Xu, Matthew R Nassar, Fuschia Sirois, Bernhard Hommel, Chenyan Zhang, Qinghua He, Jiang Qiu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Zhiyi ChenFaculty of Psychology, Southwest University, Chongqing, China.
Pan FengFaculty of Psychology, Southwest University, Chongqing, China.
Benjamin BeckerCenter for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Ting XuCenter for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Matthew R NassarDepartment of Neuroscience, Brown University, Providence, USA.
Fuschia SiroisDepartment of Psychology, University of Sheffield, Sheffield, UK.
Bernhard HommelInstitute for Psychological Research, Leiden University, Leiden, Netherlands.
Chenyan ZhangInstitute for Psychological Research, Leiden University, Leiden, Netherlands.
Qinghua HeFaculty of Psychology, Southwest University, Chongqing, China.
Jiang QiuFaculty of Psychology, Southwest University, Chongqing, China.
Li HeFaculty of Psychology, Southwest University, Chongqing, China.
Xu LeiFaculty of Psychology, Southwest University, Chongqing, China.
Hong ChenFaculty of Psychology, Southwest University, Chongqing, China.
Tingyong FengFaculty of Psychology, Southwest University, Chongqing, China.
Ministry of Education of the People's Republic of China · CNLeiden University · NLUniversity of Electronic Science and Technology of China · CNAllen Institute for Brain Science · USUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe novel coronavirus (COVID-19) pandemic has affected humans worldwide and led to unprecedented stress and mortality. Detrimental effects of the pandemic on mental health, including risk of post-traumatic stress disorder (PTSD), have become an increasing concern. The identification of prospective neurobiological vulnerability markers for developing PTSD symptom during the pandemic is thus of high importance.

methodsBefore the COVID-19 outbreak (September 20, 2019-January 11, 2020), some healthy participants underwent resting-state functional connectivity MRI (rs-fcMRI) acquisition. We assessed the PTSD symptomology of these individuals during the peak of COVID-19 pandemic (February 21, 2020-February 28, 2020) in China. This pseudo-prospective cohort design allowed us to test whether the pre-pandemic neural connectome status could predict the risk of developing PTSD symptom during the pandemic.

resultsA total of 5.60% of participants (n = 42) were identified as being high-risk to develop PTSD symptom and 12.00% (n = 90) exhibited critical levels of PTSD symptoms during the COVID-19 pandemic. Pre-pandemic measures of functional connectivity (the neural connectome) prospectively classified those with heightened risk to develop PTSD symptom from matched controls (Accuracy = 76.19%, Sensitivity = 80.95%, Specificity = 71.43%). The trained classifier generalized to an independent sample. Continuous prediction models revealed that the same connectome could accurately predict the severity of PTSD symptoms within individuals (

conclusionsThis study confirms COVID-19 break as a crucial stressor to bring risks developing PTSD symptom and demonstrates that brain functional markers can prospectively identify individuals at risk to develop PTSD symptom.

Indexed as

COVID-19Deep learningPost-traumatic stress disorderProspective diagnosis

Identifiers

PMID34430677
PMCPMC8371262
OpenAlexW3195924987

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.