ReviewAnnals of translational medicine2021
Emerging approaches to pre-hospital hemorrhage control: a narrative review.
Review in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed.
- Injectable hemostatic foam hydrogel for traumatic intra-abdominal hemorrhage.Materials today. Bio · 2025Article
- Assessment of platelet indices, beta-thromboglobulin and platelet factor IV in platelet concentrate at University of Ilorin Teaching Hospital, Nigeria.Scientific reports · 2025Article
- Damage Control Surgery in Obstetrics and Gynecology: Abdomino-Pelvic Packing in Multimodal Hemorrhage Management.Journal of clinical medicine · 2025Review
- Bioactive Polyurethane Shape Memory Polymer Foam Dressings with Enhanced Blood and Cell Interactions for Improved Wound Healing.ACS applied materials & interfaces · 2025Article
- Article
- Recent Advances in Prehospital and In-Hospital Management of Patients with Severe Trauma.Journal of clinical medicine · 2025Review
- Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage.Nature communications · 2025Article
- Emulsion-Based Encapsulation of Fibrinogen with Calcium Carbonate for Hemorrhage Control.Journal of functional biomaterials · 2025Article
- Self-expanding foam injected into the peritoneal space improves survival in a model of complex pelvic fracture and retroperitoneal exsanguination.Trauma surgery & acute care open · 2025Article
- Contemporary management of traumatic cardiac arrest and peri-arrest states: a narrative review.Journal of anesthesia, analgesia and critical care · 2024Review
- Injectable and rapidly expandable thrombin-decorated cryogels achieve rapid hemostasis and high survival rates in a swine model of lethal junctional hemorrhage.Bioactive materials · 2024Article
- Control of Haemorrhage in Orthopaedic Trauma.Journal of clinical medicine · 2024Review
- A comparative analysis of current out-of-hospital transfusion protocols to expert recommendations.Resuscitation plus · 2023Article
- Progress in injectable hydrogels for the treatment of incompressible bleeding: an update.Frontiers in bioengineering and biotechnology · 2023Review
- Emerging hemostatic materials for non-compressible hemorrhage control.National science review · 2022Review
- Development of a national out-of-hospital transfusion protocol: a modified RAND Delphi study.CMAJ openArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the United States, trauma claims the lives of over 150,000 civilians each year. In military settings, trauma and exsanguination result in 50% of combat related deaths. The majority of these deaths result from uncontrolled non-compressible hemorrhage. Non-compressible hemorrhage often results from deep vascular injuries within the torso, however can also occur secondary to penetrating injuries that involve the extremities. Given the high mortality rates for non-compressible hemorrhage, rapid and effective management of patients suffering from hemorrhage is essential to good patient outcomes. Consequently, there has been increasing interest in solutions for point-of-injury hemorrhage control in trauma and military medicine. Undoubtedly there is a great need for prehospital hemostatic interventions that can be deployed by trained and untrained personnel. Since 2001, various hemostatic agents have been developed, each with its advantages based upon the type and severity of injury, wound size, wound location, accessibility to injury site, and the coagulation status of the patient. These agents are often used in the military setting as a temporizing measure prior to definitive therapy and include techniques such as resuscitative endovascular balloon occlusion of the aorta (REBOA) and bioengineered agents including ResQFoam, RevMedx's XSTAT, Tranexamic acid (TXA), and QuikClot Combat Gauze (QCG). Here, we review the indications, composition, technique, efficacy, and outcomes of these hemostatic agents.
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