ArticleTranslational lung cancer research2021
Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features.
Article in Translational lung cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Lung cancer with breast metastasis: a case report and review of the literature.The Journal of international medical research · 2023Pooled it
- Ultrasound-guided microwave ablation for metastatic breast cancer: a 3-year follow-up case report and review of the literature.Frontiers in oncology · 2026Article
- Clinical and imaging manifestations of metastases from rare sites.Quantitative imaging in medicine and surgery · 2026Review
- Article
- Breast Mass Revealing Hidden Lung Cancer.Cureus · 2025Article
- Bilateral breast metastases from anaplastic lymphoma kinase-positive lung cancer in a male: a case report.Journal of medical case reports · 2024Article
- Primary lung adenocarcinoma with breast metastasis harboring the EML4‑ALK fusion: A case report.Oncology letters · 2024Article
- Breast metastasis of a lung carcinoma.BJR case reports · 2022Article
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8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLung cancer metastases to the breast are less common and consequently have received much less attention in clinical practice. The purpose of this study was to provide a better understanding of clinical, ultrasonographic, and immunohistochemical features of breast metastases from primary lung cancer.
methodsThis retrospective case series included patients with breast metastases from primary lung cancer between January 2012 and December 2020. Clinical features, ultrasonographic characteristics, and immunohistochemical findings were evaluated in this analysis.
resultsIn all, 7 cases (mean ± standard deviation age: 57.4±8.3 years; range, 49-70 years) were evaluated. The maximum size of breast lesions in 6 cases ranged from 1.2 to 4.5 cm, while 1 case showed a diffused pattern. Ultrasound features of breast metastases from lung cancer were irregular (5/7, 71.4%), indistinct (6/7, 85.7%), hypoechoic (7/7, 100.0%), and parallel (6/7, 85.7%) masses without calcification. Immunohistochemical staining test was positive for thyroid transcription factor 1 (TTF-1) in all patients (7/7, 100.0%), 3 cases (3/5, 60.0%) were negative for p63, 5 cases (5/5, 100.0%) were positive for cytokeratin 7 (CK7), 4 cases (4/5, 80.0%) were positive for napsin A.
conclusionsThe ultrasonographic features of lung metastases to the breast are clinically important to understand. A known history of the primary lung cancer is of great importance when evaluating patients with a breast nodule. The presence of an ipsilateral lung cancer, breast nodule and axillary lymphadenopathy should be considered with pathological and immunohistochemical data to differentiate breast metastases from a primary breast malignancy in this setting.
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