Evidence map›Paper›PMID 34430196›Full record

ArticleLeukemia research reports2021

T-cell Acute Lymphoblastic Leukemia in a Patient with Pre-existing Essential Thrombocythemia: A Case Report and Literature Review.

Georgio Medawar, Haritha Ackula, Olga Weinberg, Todd Roberts, Kapil Meleveedu

Erratum issuedOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Georgio MedawarDepartment of Internal Medicine, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, United States.
Haritha AckulaDepartment of Hematology and Oncology, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, United States.
Olga WeinbergDepartment of Pathology, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, United States.
Todd RobertsDepartment of Hematology and Oncology, Bone Marrow Transplant, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, United States.
Kapil MeleveeduDepartment of Hematology and Oncology, Bone Marrow Transplant, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, United States.
Roger Williams Medical Center · USProvidence College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The occurrence of T-cell acute lymphoblastic leukemia (T-ALL), on a background of preexisting Philadelphia-negative Myeloproliferative neoplasm is rare. Among the few reported cases where no deep molecular sequencing was performed, it was difficult to ascertain whether these leukemia's occurred de-novo or were due to the clonal progression of underlying MPN. We present a case of a 49-year-old man with a history of essential thrombocythemia who subsequently developed T-ALL. By utilizing next generation sequencing we were able to determine that these two entities originated from two distinct clones and were likely random events. We report the outcome and review the literature.

Indexed as

Essential thrombocythemiaMyeloproliferative disordersNext generation sequencingT–cell acute lymphoblastic leukemia

Identifiers

PMID34430196
PMCPMC8367827
OpenAlexW3192606851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.