Evidence map›Paper›PMID 34430048›Full record

ArticleRoyal Society open science2021

Spatio-temporal analyses reveal infectious disease-driven selection in a free-ranging ungulate.

Melanie E F LaCava, Jennifer L Malmberg, William H Edwards, Laura N L Johnson, Samantha E Allen, Holly B Ernest

Open access · goldAbstract read
In one paragraph

Article in Royal Society open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Old nodes, new tricks: optimized methods for chronic wasting disease prion detection in preserved retropharyngeal lymph nodes.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2026
    Article
  2. Novel Prion Protein Gene (bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melanie E F LaCavaWildlife Genomics and Disease Ecology Laboratory, Department of Veterinary Sciences, Program in Ecology, University of Wyoming, Laramie, WY 82071, USA.ORCID 0000-0001-7921-9184
Jennifer L MalmbergDepartment of Veterinary Sciences, Wyoming State Veterinary Laboratory, University of Wyoming, Laramie, WY 82070, USA.ORCID 0000-0001-9066-721X
William H EdwardsWyoming Game and Fish Department, Wildlife Health Laboratory, Laramie, WY 82070, USA.
Laura N L JohnsonWildlife Genomics and Disease Ecology Laboratory, Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82071, USA.ORCID 0000-0002-1130-8524
Samantha E AllenWyoming Game and Fish Department, Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA.
Holly B ErnestWildlife Genomics and Disease Ecology Laboratory, Department of Veterinary Sciences, Program in Ecology, University of Wyoming, Laramie, WY 82071, USA.ORCID 0000-0002-0205-8818
University of Wyoming · USWyoming Game and Fish Department · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious diseases play an important role in wildlife population dynamics by altering individual fitness, but detecting disease-driven natural selection in free-ranging populations is difficult due to complex disease-host relationships. Chronic wasting disease (CWD) is a fatal infectious prion disease in cervids for which mutations in a single gene have been mechanistically linked to disease outcomes, providing a rare opportunity to study disease-driven selection in wildlife. In Wyoming, USA, CWD has gradually spread across mule deer (

Indexed as

cervidchronic wasting diseasenatural selectionOdocoileus hemionusprion protein genewildlife disease

Identifiers

PMID34430048
PMCPMC8355672
OpenAlexW3192017360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.