Evidence map›Paper›PMID 34429871›Full record

ReviewClinical and translational allergy2021

Peanut allergy: Beyond the oral immunotherapy plateau.

Kelly Bruton, Paul Spill, Derek K Chu, Susan Waserman, Manel Jordana

Open access · goldAbstract readReview
In one paragraph

Review in Clinical and translational allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Peanut allergy: Beyond the oral immunotherapy plateau.Clinical and translational allergy · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kelly BrutonDepartment of Medicine McMaster Immunology Research Centre (MIRC) McMaster University Hamilton Ontario Canada.ORCID https://orcid.org/0000-0003-0817-6134
Paul SpillDepartment of Medicine McMaster Immunology Research Centre (MIRC) McMaster University Hamilton Ontario Canada.
Derek K ChuDepartment of Medicine McMaster University Hamilton Ontario Canada.
Susan WasermanDepartment of Medicine McMaster University Hamilton Ontario Canada.
Manel JordanaDepartment of Medicine McMaster Immunology Research Centre (MIRC) McMaster University Hamilton Ontario Canada.
McMaster University Medical Centre · CAPrograms for Assessment of Technology in Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are a lack of disease-modifying treatments for peanut allergy, which is lifelong in most instances. Oral immunotherapy has remained at the forefront of prospective treatments, though its efficacy is consistently undermined by the risk of adverse reactions and meager sustained effects.

aimThis review discusses the current state of oral immunotherapy, its strengths and limitations, and the future of therapeutics for the treatment of peanut allergy.

conclusionThe persistence of peanut allergy is currently attributed to reservoirs of peanut-specific memory B cells and Th2 cells, though the cellular and molecular interplay that facilitates the replenishment of peanut-specific IgE remains elusive. Uncovering these events will prove critical for identification of novel targets as we forge ahead to a new age of peanut allergy treatment with biotherapeutics.

Indexed as

food allergyIgEoral immunotherapypeanut

Identifiers

PMID34429871
PMCPMC8361810
OpenAlexW3195492417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.