Evidence map›Paper›PMID 34429772›Full record

ArticleOncology letters2021

CDK4 has the ability to regulate Aurora B and Cenpp expression in mouse keratinocytes.

Sung Hyun Lee, Liliana R L Rodriguez, Rima Majumdar, Paula L Miliani De Marval, Marcelo L Rodriguez-Puebla

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sung Hyun LeeDepartment of Molecular Biomedical Sciences, Center for Human Health and The Environment, North Carolina State University, Raleigh, NC 27607, USA.
Liliana R L RodriguezDepartment of Clinical Analysis, General Acute Hospital, Parmenio Piñeiro, Buenos Aires 1406, Argentina.
Rima MajumdarDepartment of Molecular Biomedical Sciences, Center for Human Health and The Environment, North Carolina State University, Raleigh, NC 27607, USA.
Paula L Miliani De MarvalCharles River Laboratories, Inc., Morrisville, NC 27560, USA.
Marcelo L Rodriguez-PueblaDepartment of Molecular Biomedical Sciences, Center for Human Health and The Environment, North Carolina State University, Raleigh, NC 27607, USA.

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
Roles of Cyclin D3 in Neoplastic ProliferationR01CA116328 · NCI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI RODRIGUEZ-PUEBLA, MARCELO LUIS · 2006 to 2011
$1.3M
NCI NIH HHS R01 CA116328NIEHS NIH HHS P30 ES025128
6 · The paper itself

Abstract

Cyclin-dependent kinase 4 (CDK4) is a critical molecule that regulates key aspects of cell proliferation through phosphorylation of the retinoblastoma (Rb) family of proteins. In the last few years, it has been suggested that CDK4 plays alternative roles in cell proliferation and tumorigenesis. The main aim of the present study was to define a novel CDK4 function as a transcriptional regulator of genes involved in chromosome segregation, contributing to the G

Indexed as

Aurora-Bcell-cycleCentromere Protein Pcyclin-dependent kinase 4keratinocytesskin

Identifiers

PMID34429772
PMCPMC8371965

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.