Evidence map›Paper›PMID 34429761›Full record

ArticleOncology letters2021

Histone deacetylase 1 facilitates aerobic glycolysis and growth of endometrial cancer.

Qiongwei Wu, Wenying Zhang, Yu Liu, Yuhua Huang, Huiheng Wu, Chengbin Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiongwei WuGynecology Department, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200051, P.R. China.
Wenying ZhangGynecology Department, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200051, P.R. China.
Yu LiuGynecology Department, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200051, P.R. China.
Yuhua HuangGynecology Department, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200051, P.R. China.
Huiheng WuGynecology Department, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200051, P.R. China.
Chengbin MaGynecology Department, Shanghai Changning Maternity and Infant Health Hospital, Shanghai 200051, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The deregulation of histone deacetylase 1 (HDAC1) is reportedly involved in the progression of several cancer types. However, its function in endometrial cancer remains unknown. The aim of the present study was to clarify the role of HDAC1 in aerobic glycolysis and the progression of endometrial cancer. Lentiviral vector transfection was used to up- and downregulate HDAC1 expression in HEC-1-A endometrial cancer cells. The effects of HDAC1 on cellular proliferation, apoptosis, migration, invasiveness and tumorigenesis were determined by CCK-8, flow cytometry, wound-healing, transwell chamber and

Indexed as

aerobic glycolysisepithelial-mesenchymal transitiongrowthhistone deacetylase 1migration

Identifiers

PMID34429761
PMCPMC8371952

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.