ReviewJournal of blood medicine2021
Why is Misdiagnosis of von Willebrand Disease Still Prevalent and How Can We Overcome It? A Focus on Clinical Considerations and Recommendations.
Review in Journal of blood medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The use of artificial intelligence in the prevention and management of bleeding disorders: a systematic review.Frontiers in medicine · 2025Pooled it
- Efficacy and safety of recombinant von Willebrand factor in on-demand treatment of children with von Willebrand disease: up to 4 years of phase 3/3b follow-up.Research and practice in thrombosis and haemostasis · 2026Trial
- Updated global prevalence and ethnic diversity of von Willebrand disease based on population genetics analysis.Scientific reports · 2026Article
- Prophylaxis for von Willebrand disease: Is it time for parity with established practice in hemophilia A?Therapeutic advances in hematology · 2026Review
- Beyond a century of discovery: the global and persistent burden of underdiagnosis in von Willebrand disease.Research and practice in thrombosis and haemostasis · 2026Review
- Von Willebrand disease diagnosis: from complexity to simplicity.Research and practice in thrombosis and haemostasis · 2025Article
- Acquired von Willebrand syndrome in children.Research and practice in thrombosis and haemostasis · 2025Article
- A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero?Biomolecules · 2025Review
- A 4-Week-Old Female Infant with Type 3 von Willebrand Disease Presenting with Nosebleeds and Uncontrolled Bleeding Following Surgical Frenectomy: A Clinical Case.The American journal of case reports · 2025Article
- Ratio of Von Willebrand Collagen Binding Assay and Von Willebrand Antigen Can Predict Multimer Size in Von Willebrand Disease.Haemophilia : the official journal of the World Federation of Hemophilia · 2025Article
- Laboratory Assessment of Factor VIII Inhibitors: When Is It Required? A Perspective Informed by Local Practice.Journal of clinical medicine · 2024Article
- Laboratory diagnosis of von Willebrand disease in the age of the new guidelines: considerations based on geography and resources.Research and practice in thrombosis and haemostasis · 2023Review
- To Clot or Not to Clot: Is That the Question?Journal of clinical medicine · 2023Article
- Laboratory-based inequity in thrombosis and hemostasis: review of the evidence.Research and practice in thrombosis and haemostasis · 2023Review
- Laboratory Testing for von Willebrand Factor: Factor VIII Binding for the Diagnosis or Exclusion of Type 2N von Willebrand Disease: An Update.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Post-analytical Issues in Hemostasis and Thrombosis Testing: An Update.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Laboratory Testing for von Willebrand Disease Using a Composite Rapid 3-Test Chemiluminescence-Based von Willebrand Factor Assay Panel.Methods in molecular biology (Clifton, N.J.) · 2023Article
- An Overview of Laboratory Testing for ADAMTS13.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Hemostasis and Thrombosis: An Overview Focusing on Associated Laboratory Testing to Diagnose and Help Manage Related Disorders.Methods in molecular biology (Clifton, N.J.) · 2023Review
- The Intriguing Connections between von Willebrand Factor, ADAMTS13 and Cancer.Healthcare (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite von Willebrand disease (VWD) being the most common inherited bleeding disorder, its accurate diagnosis is frequently shrouded by diagnostic pitfalls. VWD is frequently under-diagnosed, over-diagnosed and misdiagnosed, leading to significant avoidable patient morbidity and health care system burden. At the heart of this dilemma lies the heterogeneity and complexity of von Willebrand factor (VWF) and associated defects, and the necessity of coalescing clinical and laboratory features to obtain an accurate diagnosis. Common pitfalls include poor clinical and scientific understanding and familiarity with VWD, incomplete clinical history and lack of routine use of standardised bleeding assessment tools (BAT), difficulty in accessing a comprehensive repertoire of laboratory tests, significant pre-analytical, analytical and post-analytical issues, and lack of expertise in laboratory testing and interpretation. Errors, resulting in under-diagnosis, over-diagnosis, and misdiagnosis of VWD, are presented and discussed. Strategies to minimise errors include better education of clinicians and laboratory staff on VWD, routine use of validated BAT, utilising a comprehensive gamut of laboratory investigations according to a standardised algorithm, and repeating testing to minimise pre-analytical errors. Recommendations on appropriate patient selection for VWD testing, how VWD should be investigated in the laboratory, and how to ensure test results are accurately interpreted in the correct clinical context are detailed.
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Registered trials
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