ArticleScientific reports2021
Heat hardening enhances mitochondrial potential for respiration and oxidative defence capacity in the mantle of thermally stressed Mytilus galloprovincialis.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- Climate Change and Contaminants of Emerging Concern: Enrofloxacin Effects on Manila Clam (Ruditapes philippinarum) Under Simulated Ocean Warming.Journal of applied toxicology : JAT · 2026Article
- Cell-cycle genes in the mussel Mytilus galloprovincialis are cued by aerial heat stress in a fluctuating tidal environment.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Food-dependent activation of one-carbon metabolism during heat shock in Mytilus californianus.The Journal of experimental biology · 2026Article
- Temperature-Dependent Modulation of Cardiac Metabolism, Post-Injury Survival and Regenerative Rate in Axolotls.Metabolites · 2026Article
- Mussels enhance digestive enzyme activity in preparation for stressful fluctuating environments.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Genome-wide transcriptomic analysis reveals autophagy and HSP70-mediated mechanisms underlying thermal stress adaptation in Mytilus coruscus.BMC genomics · 2025Article
- Molecular Insights into the Genesis of Heat Hardening in Marine Bivalves.Antioxidants (Basel, Switzerland) · 2025Article
- Article
- Differential Mitochondrial Genome Expression of Four Skink Species Under High-Temperature Stress and Selection Pressure Analyses in Scincidae.Animals : an open access journal from MDPI · 2025Article
- Ecophysiological responses to heat waves in the marine intertidal zone.The Journal of experimental biology · 2025Review
- Heat Hardening Ameliorates Apoptotic and Inflammatory Effects Through Increased Autophagy in Mussels.Marine biotechnology (New York, N.Y.) · 2024Article
- Cellular stress and epigenetic regulation in adult stem cells.Life science alliance · 2024Review
- Context-dependent antioxidant defense system (ADS)-based stress memory in response to recurrent environmental challenges in congeneric invasive species.Marine life science & technology · 2024Article
- Oxidative Damage and Antioxidants as Markers for the Selection of Emersion Hardening Treatments in GreenshellAntioxidants (Basel, Switzerland) · 2024Article
- Metabolite Changes ofMetabolites · 2023Article
- The Eco-Immunological Relevance of the Anti-Oxidant Response in Invasive Molluscs.Antioxidants (Basel, Switzerland) · 2023Review
- Heat hardening enhances metabolite-driven thermoprotection in the Mediterranean musselFrontiers in physiology · 2023Article
- Aquaponics as a Promising Strategy to Mitigate Impacts of Climate Change on Rainbow Trout Culture.Animals : an open access journal from MDPI · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectotherms are exposed to a range of environmental temperatures and may face extremes beyond their upper thermal limits. Such temperature extremes can stimulate aerobic metabolism toward its maximum, a decline in aerobic substrate oxidation, and a parallel increase of anaerobic metabolism, combined with ROS generation and oxidative stress. Under these stressful conditions, marine organisms recruit several defensive strategies for their maintenance and survival. However, thermal tolerance of ectothermic organisms may be increased after a brief exposure to sub-lethal temperatures, a process known as "hardening". In our study, we examined the ability of M. galloprovincialis to increase its thermal tolerance under the effect of elevated temperatures (24, 26 and 28 °C) through the "hardening" process. Our results demonstrate that this process can increase the heat tolerance and antioxidant defense of heat hardened mussels through more efficient ETS activity when exposed to temperatures beyond 24 °C, compared to non-hardened individuals. Enhanced cell protection is reflected in better adaptive strategies of heat hardened mussels, and thus decreased mortality. Although hardening seems a promising process for the maintenance of aquacultured populations under increased seasonal temperatures, further investigation of the molecular and cellular mechanisms regulating mussels' heat resistance is required.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.