ArticleScientific reports2021
C. elegans-based chemosensation strategy for the early detection of cancer metabolites in urine samples.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
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- HarnessingSensors (Basel, Switzerland) · 2025Review
- Strain-specific effects of Desulfovibrio on neurodegeneration and oxidative stress in a Caenorhabditis elegans PD model.NPJ Parkinson's disease · 2025Article
- Advancing Veterinary Oncology: Next-Generation Diagnostics for Early Cancer Detection and Clinical Implementation.Animals : an open access journal from MDPI · 2025Review
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- The chemotactic response of Caenorhabditis elegans represents a promising tool for the early detection of cancer.Discover oncology · 2024Article
- N-NOSE Proves Effective for Early Cancer Detection: Real-World Data from Third-Party Medical Institutions.Biomedicines · 2024Article
- A non-invasive screening method usingBiochemistry and biophysics reports · 2024Article
- Worm-Based Diagnosis Combining Microfluidics toward Early Cancer Screening.Micromachines · 2024Review
- Non-Invasive Blood Pressure Tracking of Spontaneous Hypertension Rats Using an Electronic Nose.Sensors (Basel, Switzerland) · 2023Article
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- Pancreatic Cancer and Detection Methods.Biomedicines · 2023Review
- Hypoxia and lactate influence VOC production in A549 lung cancer cells.Frontiers in molecular biosciences · 2023Article
- The recurrent pathogenic Pro890Leu substitution in CLTC causes a generalized defect in synaptic transmission inFrontiers in molecular neuroscience · 2023Article
- A new detection method for canine and feline cancer using the olfactory system of nematodes.Biochemistry and biophysics reports · 2022Article
- Review
- Pond Assay for the Sensory Systems ofBiology · 2022Article
- Non-invasive cancer detection in canine urine throughFrontiers in veterinary science · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Chemosensory receptors play a crucial role in distinguishing the wide range of volatile/soluble molecules by binding them with high accuracy. Chemosensation is the main sensory modality in organisms lacking long-range sensory mechanisms like vision/hearing. Despite its low number of sensory neurons, the nematode Caenorhabditis elegans possesses several chemosensory receptors, allowing it to detect about as many odorants as mammals. Here, we show that C. elegans displays attraction towards urine samples of women with breast cancer, avoiding control ones. Behavioral assays on animals lacking AWC sensory neurons demonstrate the relevance of these neurons in sensing cancer odorants: calcium imaging on AWC increases the accuracy of the discrimination (97.22%). Also, chemotaxis assays on animals lacking GPCRs expressed in AWC allow to identify receptors involved in binding cancer metabolites, suggesting that an alteration of a few metabolites is sufficient for the cancer discriminating behavior of C. elegans, which may help identify a fundamental fingerprint of breast cancer.
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Registered trials
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