Evidence map›Paper›PMID 34429451›Full record

ArticleScientific reports2021

Integrative genetic, genomic and transcriptomic analysis of heat shock protein and nuclear hormone receptor gene associations with spontaneous preterm birth.

Johanna M Huusko, Heli Tiensuu, Antti M Haapalainen, Anu Pasanen, Pinja Tissarinen, Minna K Karjalainen, Ge Zhang, Kaare Christensen, Kelli K Ryckman, Bo Jacobsson and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Genetics, epigenetics, and transcriptomics of preterm birth.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022
    Review
  8. Article
  9. Article
  10. Preterm Labor, a Syndrome Attributed to the Combination of External and Internal Factors.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 5 countries.

Johanna M HuuskoPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Heli TiensuuPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Antti M HaapalainenPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Anu PasanenPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Pinja TissarinenPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Minna K KarjalainenPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Ge ZhangDivision of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
Kaare ChristensenInstitute of Public Health, University of Southern Denmark, Odense, Denmark.
Kelli K RyckmanDepartment of Epidemiology, College of Public Health and Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Bo JacobssonDepartment of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jeffrey C MurrayDepartment of Pediatrics, University of Iowa, Iowa City, Iowa, USA.
Stephen F KingsmoreRady Children's Institute for Genomic Medicine, Rady Children's Hospital, San Diego, CA, USA.
Mikko HallmanPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland.
Louis J MugliaDivision of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, OH, USA.
Mika RämetPEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland. mika.ramet@oulu.fi.
University of Oulu · FIOulu University Hospital · FICincinnati Children's Hospital Medical Center · USUniversity of Iowa · USChildren’s Institute · USTampere University · FIUniversity of Gothenburg · SEUniversity of Southern Denmark · DK

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Genome Wide Association Coordinating CenterU01HG004446 · NHGRI · UNIVERSITY OF WASHINGTON · PI WEIR, BRUCE S. · 2007 to 2011
$6.6M
Integrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseasesR01HD101669 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI FREATHY, RACHEL, JACOBSSON, BO · 2021 to 2024
$2.1M
Genome-wide association studies of prematurity and its complicationsU01HG004423 · NHGRI · UNIVERSITY OF IOWA · PI MURRAY, JEFFREY C · 2007 to 2010
$1.5M
NHGRI NIH HHS U01 HG004423NHGRI NIH HHS U01 HG004446NICHD NIH HHS R01 HD101669NIEHS NIH HHS N01 ES075558NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

Heat shock proteins are involved in the response to stress including activation of the immune response. Elevated circulating heat shock proteins are associated with spontaneous preterm birth (SPTB). Intracellular heat shock proteins act as multifunctional molecular chaperones that regulate activity of nuclear hormone receptors. Since SPTB has a significant genetic predisposition, our objective was to identify genetic and transcriptomic evidence of heat shock proteins and nuclear hormone receptors that may affect risk for SPTB. We investigated all 97 genes encoding members of the heat shock protein families and all 49 genes encoding nuclear hormone receptors for their potential role in SPTB susceptibility. We used multiple genetic and genomic datasets including genome-wide association studies (GWASs), whole-exome sequencing (WES), and placental transcriptomics to identify SPTB predisposing factors from the mother, infant, and placenta. There were multiple associations of heat shock protein and nuclear hormone receptor genes with SPTB. Several orthogonal datasets supported roles for SEC63, HSPA1L, SACS, RORA, and AR in susceptibility to SPTB. We propose that suppression of specific heat shock proteins promotes maintenance of pregnancy, whereas activation of specific heat shock protein mediated signaling may disturb maternal-fetal tolerance and promote labor.

Indexed as

AdultFemaleHeat-Shock ProteinsHSP70 Heat-Shock ProteinsHumansInfant, PrematureMaleMolecular ChaperonesNuclear Receptor Subfamily 1, Group F, Member 1PlacentaPregnancyPremature BirthReceptors, AndrogenRNA-Binding ProteinsTranscriptomeAR protein, humanHeat-Shock ProteinsHSP70 Heat-Shock ProteinsHSPA1L protein, humanMolecular ChaperonesNuclear Receptor Subfamily 1, Group F, Member 1Receptors, AndrogenRNA-Binding ProteinsRORA protein, humanSACS protein, humanSEC63 protein, human

Identifiers

PMID34429451
PMCPMC8384995
OpenAlexW3195820870

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.