Evidence map›Paper›PMID 34429440›Full record

ArticleScientific reports2021

Megavolt bremsstrahlung measurements from linear induction accelerators demonstrate possible use as a FLASH radiotherapy source to reduce acute toxicity.

Stephen E Sampayan, Kristin C Sampayan, George J Caporaso, Yu-Jiuan Chen, Steve Falabella, Steven A Hawkins, Jason Hearn, James A Watson, Jan-Mark Zentler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stephen E SampayanLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA. sampayan1@llnl.gov.
Kristin C SampayanOpcondys, Inc., 600 Commerce Court, Manteca, CA, 95336, USA.
George J CaporasoLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA.
Yu-Jiuan ChenLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA.
Steve FalabellaLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA.
Steven A HawkinsLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA.
Jason HearnDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA.
James A WatsonLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA.
Jan-Mark ZentlerLawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA, 94551, USA.
Lawrence Livermore National Laboratory · USUniversity of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies indicate better efficacy and healthy tissue sparing with high dose-rate FLASH radiotherapy (FLASH-RT) cancer treatment. This technique delivers a prompt high radiation dose rather than fractional doses over time. While some suggest thresholds of > 40 Gy s

Indexed as

ElectronsHumansParticle AcceleratorsRadiotherapyRadiotherapy Dosage

Identifiers

PMID34429440
PMCPMC8385032
OpenAlexW3165287196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.