ArticleNature communications2021
A non-enzymatic, isothermal strand displacement and amplification assay for rapid detection of SARS-CoV-2 RNA.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Performance of AI Tools in Citing Retracted Literature : Content Analysis.Journal of medical Internet research · 2026Article
- Spherical Nucleic Acid Stabilized Cage Type Three-Dimensional Electrochemiluminescence Probe for Sensitive and Amplification-Free Diagnosis of Infectious Diseases.Exploration (Beijing, China) · 2026Article
- Digital Detection of DNA via Impedimetric Tracking of Probe Nanoparticles.Nano letters · 2025Article
- Ultrasensitive detection of antimicrobial resistance genes using hybridization chain reaction employing carbon dots.RSC advances · 2024Article
- Preamplification-free viral RNA diagnostics with single-nucleotide resolution using MARVE, an origami paper-based colorimetric nucleic acid test.Nature protocols · 2024Review
- Mimicking a Cellular Crowding Environment for Enzyme-Free Paper-Based Nucleic Acid Tests at the Point of Care.ACS sensors · 2024Article
- Y-switch: a spring-loaded synthetic gene switch for robust DNA/RNA signal amplification and detection.Nucleic acids research · 2024Article
- Article
- Rapid Nucleic Acid Diagnostic Technology for Pandemic Diseases.Molecules (Basel, Switzerland) · 2024Review
- Advancements in Airborne Viral Nucleic Acid Detection with Wearable Devices.Advanced sensor research · 2024Article
- Mimicking anbioRxiv : the preprint server for biology · 2024Article
- On-site airborne pathogen detection for infection risk mitigation.Chemical Society reviews · 2023Review
- Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives.Chemical science · 2023Review
- SERS-ELISA using silica-encapsulated Au core-satellite nanotags for sensitive detection of SARS-CoV-2.Sensors and actuators. B, Chemical · 2023Article
- Superior possibilities and upcoming horizons for nanoscience in COVID-19: noteworthy approach for effective diagnostics and management of SARS-CoV-2 outbreak.Chemicke zvesti · 2023Review
- Nuclear envelope morphology change upon repetitive treatment with modified antisense oligonucleotides targeting Hutchinson-Gilford Progeria Syndrome.Biochemistry and biophysics reports · 2023Article
- Target-mediated self-assembly of DNA networks for sensitive detection and intracellular imaging of APE1 in living cells.Chemical science · 2023Article
- Plasmonic nanostructure-enhanced Raman scattering for detection of SARS-CoV-2 nucleocapsid protein and spike protein variants.Analytica chimica acta · 2023Article
- Rapid microRNA detection method based on DNA strand displacement for ovarian cancer cells.Journal of Cancer · 2023Article
- Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics.Advances in experimental medicine and biology · 2023Article
Corrections and comments
- Retraction · 2025-05-17Investigation by Third Party · Results Not Reproducible · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current nucleic acid signal amplification methods for SARS-CoV-2 RNA detection heavily rely on the functions of biological enzymes which imposes stringent transportation and storage conditions, high cost and global supply shortages. Here, a non-enzymatic whole genome detection method based on a simple isothermal signal amplification approach is developed for rapid detection of SARS-CoV-2 RNA and potentially any types of nucleic acids regardless of their size. The assay, termed non-enzymatic isothermal strand displacement and amplification (NISDA), is able to quantify 10 RNA copies.µL
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