Evidence map›Paper›PMID 34429358›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Histone H3K27 methylation-mediated repression of

Yan Yang, Tujing Zhao, Zheng Li, Wenliang Qian, Jian Peng, Ling Wei, Dongqin Yuan, Yaoyao Li, Qingyou Xia, Daojun Cheng

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Review
  3. Stage-Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Optogenetic control of transition to metamorphosis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Schlank orchestrates insect developmental transition by switching H3K27 acetylation to trimethylation in the prothoracic gland.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Identification of Growth-Related GeneAnimals : an open access journal from MDPI · 2024
    Article
  14. Article
  15. Knockdown ofBiology · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Juvenile Hormone Studies inFrontiers in physiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yan YangState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0002-3277-978X
Tujing ZhaoState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0003-3325-4480
Zheng LiState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0002-7803-5401
Wenliang QianState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0002-2222-6997
Jian PengState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0002-7858-0709
Ling WeiSchool of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0002-7461-9397
Dongqin YuanState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0002-9908-9353
Yaoyao LiState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China.
Qingyou XiaState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China; chengdj@swu.edu.cn xiaqy@swu.edu.cn.
Daojun ChengState Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing 400715, China; chengdj@swu.edu.cn xiaqy@swu.edu.cn.ORCID 0000-0002-4612-0046
Southwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insect development is cooperatively orchestrated by the steroid hormone ecdysone and juvenile hormone (JH). The polycomb repressive complex 2 (PRC2)-mediated histone H3K27 trimethylation (H3K27me3) epigenetically silences gene transcription and is essential for a range of biological processes, but the functions of H3K27 methylation in insect hormone action are poorly understood. Here, we demonstrate that H3K27 methylation-mediated repression of

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBombyxDrosophilaDrosophila ProteinsEcdysoneEpigenesis, GeneticGene Expression Regulation, DevelopmentalHistonesInsect ProteinsJuvenile HormonesLarvaMethylationPupaRepressor ProteinsSignal TransductionBasic Helix-Loop-Helix ProteinsDrosophila ProteinsEcdysonehairy protein, DrosophilaHistonesInsect ProteinsJuvenile HormonesRepressor ProteinsSteroidsecdysone biosynthesisH3K27 methylationHairyjuvenile hormonerepression

Identifiers

PMID34429358
PMCPMC8536348
OpenAlexW3195582890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.