ArticleCancer discovery2022
Systematic Profiling of
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Article in Cancer discovery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed.
- Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration.bioRxiv : the preprint server for biology · 2026Article
- Germline and somatic variants in DNMT3A and other clonal haematopoiesis of indeterminate potential genes contribute to pulmonary arterial hypertension.European heart journal · 2026Article
- Oleuropein Regulates GSDME Methylation to Inhibit Tumor Growth and Enhance Radiosensitivity in Head and Neck Squamous Cell Carcinoma Via Inducing Pyroptosis.Applied biochemistry and biotechnology · 2026Article
- Recent Advances in Searching for DNMT Inhibitors and Their Potential Application in Treating Human Diseases.International journal of molecular sciences · 2026Review
- Mutation-specific impairment of TET2 and DNMT3A enzymatic activity predicts clonal hematopoiesis disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Role of DCAF8 in Mammary Ductal Elongation and Branching Morphogenesis.Journal of mammary gland biology and neoplasia · 2026Article
- Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease.Nature communications · 2026Article
- PRC2-Related Epigenetic Age Acceleration in Acute Myeloid Leukemia with DNMT3A and IDH2 Mutations.Advanced biology · 2026Article
- Convergent DNA methylation abnormalities at enhancers and bivalent promoters in human growth disorders.Epigenetics & chromatin · 2025Article
- Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis.Blood · 2025Article
- Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity.Cell stem cell · 2025Article
- Epigenetic dysregulation in acute myeloid leukemia.Seminars in hematology · 2025Review
- Article
- Article
- Stable ExpressedMedComm · 2025Article
- Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis.Blood advances · 2025Article
- Significance of targeting DNMT3A mutations in AML.Annals of hematology · 2025Review
- Identification of a novel unfolded protein response related signature for predicting the prognosis of acute myeloid leukemia.Scientific reports · 2025Article
- Characterization of Rationally Designed CRISPR/Cas9-Based DNA Methyltransferases with Distinct Methyltransferase and Gene Silencing Activities in Human Cell Lines and Primary Human T Cells.ACS synthetic biology · 2025Article
- The Role of the DNA Methyltransferase Family and the Therapeutic Potential of DNMT Inhibitors in Tumor Treatment.Current oncology (Toronto, Ont.) · 2025Review
Corrections and comments
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Authors and funding
25 authors.
Yung-Hsin HuangProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-5180-934X
Chun-Wei ChenStem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Venkatasubramaniam SundaramurthyStem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Mikołaj SłabickiDepartment of Medical Oncology, Dana-Farber Cancer Institute, Division of Hematology, Brigham and Women's Hospital, and Broad Institute of MIT and Harvard, Cambridge, Massachusetts.ORCID 0000-0001-6317-9296
Dapeng HaoDivision of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-9043-371X
Caroline J WatsonDepartment of Oncology, University of Cambridge, Cambridge; Early Detection Programme, CRUK Cambridge Cancer Centre, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-8351-268X
Ayala TovyStem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Jaime M ReyesStem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Olga DakhovaSection of Hematology-Oncology, Department of Pediatrics, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Brielle R CrovettiStem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.
Christina GalonskaDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Minjung LeeCenter for Translational Cancer Research, Texas A&M University, Institute of Biosciences and Technology, Houston, Texas.
Lorenzo BrunettiStem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas.ORCID 0000-0003-2624-8576
Yubin ZhouCenter for Translational Cancer Research, Texas A&M University, Institute of Biosciences and Technology, Houston, Texas.
Katrina Tatton-BrownDivision of Genetics and Epidemiology, Institute of Cancer Research, South West Thames Regional Genetics Service, St George's University Hospitals NHS Foundation Trust, London, United Kingdom.
Yun HuangCenter for Translational Cancer Research, Texas A&M University, Institute of Biosciences and Technology, Houston, Texas.
Xiaodong ChengDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Alexander MeissnerDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Peter J M ValkDepartment of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Lionel Van MaldergemCentre de Génétique Humaine and Integrative and Cognitive Neuroscience Research Unit EA481, University of Franche-Comté, Besançon, France.
Mathijs A SandersDepartment of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jamie R BlundellDepartment of Oncology, University of Cambridge, Cambridge; Early Detection Programme, CRUK Cambridge Cancer Centre, University of Cambridge, Cambridge, United Kingdom.
Wei LiDivision of Biostatistics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas.
Benjamin L EbertDepartment of Medical Oncology, Dana-Farber Cancer Institute, Division of Hematology, Brigham and Women's Hospital, and Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Margaret A GoodellProgram in Developmental Biology, Baylor College of Medicine, Houston, Texas. goodell@bcm.edu.ORCID 0000-0003-1111-2932
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9MUM1HG006348: Cas9 Genome Integrity Supplemental ProposalUM1HG006348 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI Jason D. Heaney, Chih-Wei Logan Hsu · 2016 to 2026
$47.5MWnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Matteo Pellegrini · 2011 to 2026
$29.3MREGULATION OF HEMATOPOIETIC PROGENITORS BY DE NOVO DNA METHYLATIONR01DK092883 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2012 to 2024
$7.4MDNMT3A in Development of Hematologic MalignanciesR01CA183252 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL · 2014 to 2026
$7.1MTransfer: DNA Methylation Canyons in Human Cancers: Methods, Target Genes and Functional ConsequencesR01CA228140 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2019 to 2023
$2.8MMOLECULAR CONTROL OF CALCIUM INFLUX AT THE ER-PLASMA MEMBRANE JUNCTIONSR01GM112003 · NIGMS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ZHOU, YUBIN · 2014 to 2022
$2.7MComputational and Experimental Modeling of Epigenetic DNA MethylationR01HG007538 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LI, WEI · 2014 to 2018
$1.9MTET-mediated epigenetic regulation in cardiac development.R01HL134780 · NHLBI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HUANG, YUN · 2018 to 2022
$1.9MBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kThe role of DNMT3A in gene regulation and stem cell expansionK00CA222736 · NCI · STANFORD UNIVERSITY · PI HUANG, YUNG-HSIN · 2020 to 2023
$379kRegulation of Hematopoietic Progenitors by de novo DNA MethylationR56DK092883 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2011 to 2011
$344kCancer Research UK 29749NCI NIH HHS F99 CA222736NCI NIH HHS K00 CA222736NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA183252NCI NIH HHS R01 CA228140NCRR NIH HHS S10 RR024574NHGRI NIH HHS R01 HG007538NHGRI NIH HHS UM1 HG006348NHLBI NIH HHS R01 HL134780NIDDK NIH HHS R01 DK092883NIDDK NIH HHS R56 DK092883NIGMS NIH HHS R01 GM112003
Abstract
Clonal hematopoiesis is a prevalent age-related condition associated with a greatly increased risk of hematologic disease; mutations in DNA methyltransferase 3A (
Indexed as
AnimalsDNA Methyltransferase 3AHEK293 CellsHumansLeukemia, Myeloid, AcuteLeukocytes, MononuclearMiceMutation, MissenseUbiquitin-Protein LigasesDNA Methyltransferase 3AUbiquitin-Protein Ligases
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.