Evidence map›Paper›PMID 34429169›Full record

ReviewLaboratory animal research2021

Experimental animal models for diabetes and its related complications-a review.

Chidhambara Priya Dharshini Kottaisamy, Divya S Raj, V Prasanth Kumar, Umamaheswari Sankaran

Abstract readReview
In one paragraph

Review in Laboratory animal research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  3. Review
  4. Review
  5. Whole-Genome-Guided Functional Characterization ofFoods (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The Role of Novel Biomarkers in the Early Management of Peripheral Diabetic Neuropathy.Central nervous system agents in medicinal chemistry · 2026
    Review
  15. Review
  16. Article
  17. Journal of microbiology and biotechnology · 2025
    Article
  18. Review
  19. Review
  20. Review

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chidhambara Priya Dharshini KottaisamyDepartment of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, 627 012, Tamil Nadu, India.ORCID http://orcid.org/0000-0003-4518-7633
Divya S RajDepartment of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, 627 012, Tamil Nadu, India.ORCID http://orcid.org/0000-0001-5804-1241
V Prasanth KumarDepartment of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, 627 012, Tamil Nadu, India.
Umamaheswari SankaranDepartment of Biotechnology, Manonmaniam Sundaranar University, Tirunelveli, 627 012, Tamil Nadu, India. umamsu@gmail.com.ORCID http://orcid.org/0000-0002-5910-5881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one of the fastest growing public health problems in the world. It is characterized by hyperglycemia, a condition with high glucose level in the blood plasma resulting from defects in insulin secretion or its action and in some cases both the impairment in secretion and also action of insulin coexist. Historically, animal models have played a critical role in exploring and describing malady pathophysiology and recognizable proof of targets and surveying new remedial specialists and in vivo medicines. In the present study, we reviewed the experimental models employed for diabetes and for its related complications. This paper reviews briefly the broad chemical induction of alloxan and streptozotocin and its mechanisms associated with type 1 and type 2 diabetes. Also we highlighted the different models in other species and other animals.

Indexed as

AlloxanAnimal modelsComplicationsDiabetesStreptozotocin

Identifiers

PMID34429169
PMCPMC8385906

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.