Evidence map›Paper›PMID 34429153›Full record

ArticleArthritis research & therapy2021

Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging.

Nico Andreas, Sylvia Müller, Nicole Templin, Paul M Jordan, Harald Schuhwerk, Michael Müller, Jana Gerstmeier, Laura Miek, Saskia Andreas, Oliver Werz and 1 more

Open access · goldAbstract read
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In one paragraph

Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Nico AndreasInstitute of Immunology, University Hospital Jena, Leutragraben 3, 07743, Jena, Germany. nico.andreas@med.uni-jena.de.ORCID 0000-0002-4591-7037
Sylvia MüllerInstitute of Immunology, University Hospital Jena, Leutragraben 3, 07743, Jena, Germany.
Nicole TemplinInstitute of Immunology, University Hospital Jena, Leutragraben 3, 07743, Jena, Germany.
Paul M JordanDepartment of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University, Philosophenweg 14, 07743, Jena, Germany.
Harald SchuhwerkInstitute of Immunology, University Hospital Jena, Leutragraben 3, 07743, Jena, Germany.
Michael MüllerInstitute of Immunology, University Hospital Jena, Leutragraben 3, 07743, Jena, Germany.
Jana GerstmeierDepartment of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University, Philosophenweg 14, 07743, Jena, Germany.
Laura MiekDepartment of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University, Philosophenweg 14, 07743, Jena, Germany.
Saskia AndreasDepartment of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University, Philosophenweg 14, 07743, Jena, Germany.
Oliver WerzDepartment of Pharmaceutical/Medicinal Chemistry, Friedrich Schiller University, Philosophenweg 14, 07743, Jena, Germany.
Thomas KamradtInstitute of Immunology, University Hospital Jena, Leutragraben 3, 07743, Jena, Germany. immunologie@med.uni-jena.de.
Jena University Hospital · DEFriedrich Schiller University Jena · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of rheumatoid arthritis is correlated with age. In this study, we analyzed the association of the incidence and severity of glucose-6-phosphate isomerase (G6PI)-induced arthritis with age in two different mouse strains.

methodsYoung and very old mice from two different arthritis-susceptible wild-type mouse strains were analyzed after a single subcutaneous injection of G6PI s.c. The metabolism and the function of synoviocytes were analyzed in vitro, the production of bioactive lipid mediators by myeloid cells and synoviocytes was assessed in vitro and ex vivo by UPLC-MS-MS, and flow cytometry was used to verify age-related changes of immune cell composition and function.

resultsWhile the severity of arthritis was independent from age, the onset was delayed in old mice. Old mice showed common signs of immune aging like thymic atrophy associated with decreased CD4

conclusionWhile old mice show a higher baseline of inflammatory functions, this does not result in increased reaction towards self-antigens in arthritis-susceptible mouse strains. Together, our data from two different mouse strains show that the susceptibility for G6PI-induced arthritis is not age-dependent.

Indexed as

Arthritis, ExperimentalGlucose-6-Phosphate IsomeraseAgingAnimalsChromatography, LiquidImmunizationIncidenceMiceTandem Mass SpectrometryGlucose-6-Phosphate IsomeraseAgeArthritisFLSG6PISPMT cells

Identifiers

PMID34429153
PMCPMC8383389
OpenAlexW3195972186

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.