Evidence map›Paper›PMID 34429137›Full record

Trial reportJournal of cardiothoracic surgery2021

Balanced forced-diuresis compared to control as a reno-protective approach in cardiac surgery: secondary outcome of a randomized controlled trial, assessment of neutrophil gelatinase-associated lipocalin levels.

Heyman Luckraz, Ramesh Giri, Benjamin Wrigley, Kumaresan Nagarajan, Eshan Senanayake, Emma Sharman, Lawrence Beare, Alan Nevill

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cardiothoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02974946 (Kidney Protection Using the RenalGuard® System in Cardiac Surgery), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02974946 nacompletednot on this map

Kidney Protection Using the RenalGuard® System in Cardiac Surgery

TypeinterventionalSponsorThe Royal Wolverhampton Hospitals NHS TrustRan2017 to 2019Enrolled220ConditionsAcute Renal InjuryArmsRenalGuard
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Heyman LuckrazHeart-Centre, American Hospital, PO Box 5566, Dubai, UAE. HeymanLuckraz@aol.com.ORCID http://orcid.org/0000-0003-1218-1243
Ramesh GiriHeart and Lung Centre, Wolverhampton, WV10 0QP, UK.
Benjamin WrigleyHeart and Lung Centre, Wolverhampton, WV10 0QP, UK.
Kumaresan NagarajanHeart and Lung Centre, Wolverhampton, WV10 0QP, UK.
Eshan SenanayakeHeart and Lung Centre, Wolverhampton, WV10 0QP, UK.
Emma SharmanHeart and Lung Centre, Wolverhampton, WV10 0QP, UK.
Lawrence BeareUniversity Hospitals of North Midlands, Stoke-on-Trent, ST4 6QG, UK.
Alan NevillFaculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, WS1 3BD, UK.
American University in Dubai · AEUniversity Hospitals of North Midlands NHS Trust · GBUniversity of Wolverhampton · GB

Funding

National Institute for Health Research NIHR ID: 32769
6 · The paper itself

Abstract

backgroundNeutrophil gelatinase-associated lipocalin (NGAL) is a recognised biomarker for acute kidney injury (AKI).This study investigated the impact of balanced forced-diuresis using RenalGuard® system (RG), in reducing acute kidney injury (AKI) rates and the associated NGAL levels (6-h post-CPB plasma level) post adult cardiac surgery with cardiopulmonary bypass (CPB).

methodsPatients included in the study were at high-risk for AKI post cardiac surgery, namely history of diabetes and/or anaemia, e-GFR 20-60 ml/min/1.73 m

resultsPre and intra-operative characteristics between the two groups were similar (p > 0.05) including the pre-op NGAL levels, the oxygen delivery (ecDO

conclusionsOverall, the 6-h post-CPB plasma NGAL levels were significantly higher in patients who developed AKI. Patients managed with the novel approach of balanced forced-diuresis, provided by the RenalGuard® system, had a lower AKI rate and lower NGAL levels indicating a lesser degree of renal tissue injury. Trial registration ClinicalTrials.gov website, NCT02974946, https://clinicaltrials.gov/ct2/show/NCT02974946 .

Indexed as

Acute Kidney InjuryCardiac Surgical ProceduresAcute-Phase ProteinsAdultBiomarkersCreatinineDiuresisHumansLipocalin-2LipocalinsPredictive Value of TestsProto-Oncogene ProteinsAcute-Phase ProteinsBiomarkersCreatinineLipocalin-2LipocalinsProto-Oncogene ProteinsAcute kidney injuryBalanced forced-diuresisCardiac surgeryNeutrophil gelatinase-associated lipocalinRenalGuard® system

Identifiers

PMID34429137
PMCPMC8386062
OpenAlexW3134229938

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.