ArticleAnnals of clinical microbiology and antimicrobials2021
The severity and risk factors for mortality in immunocompromised adult patients hospitalized with influenza-related pneumonia.
Article in Annals of clinical microbiology and antimicrobials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Burden of Respiratory Syncytial Virus Infection in Immunocompromised Adults: A Systematic Review of the Evidence From High-Income Countries.Infectious diseases and therapy · 2026Pooled it
- Human Influenza Virus Infection: A Focus on Key Host Determinants Linked to Clinical Disease Severity.Viruses · 2026Review
- Risk perception and influenza vaccine hesitancy among university students in Saudi Arabia.Frontiers in pharmacology · 2026Article
- Serum cytokines during acute respiratory infection and relationship to age.bioRxiv : the preprint server for biology · 2025Article
- Chronic Diseases and Influenza Vaccines.Vaccines · 2025Review
- The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia.Respiratory research · 2025Article
- Clinical features, pathogens, and prognosis of immunocompromised host pneumonia in patients with malignancies.Frontiers in cellular and infection microbiology · 2025Article
- Serum Cytokines During Acute Respiratory Infection and Relationship to Age.Journal of cellular immunology · 2025Article
- Patients with influenza admitted to a tertiary-care hospital in Riyadh between 2018 and 2022: characteristics, outcomes and factors associated with ICU admission and mortality.BMC pulmonary medicine · 2024Article
- Article
- Review of the unmet medical need for vaccination in adults with immunocompromising conditions: An Indian perspective.Human vaccines & immunotherapeutics · 2023Review
- Severe forms of influenza infections admitted in intensive care units: Analysis of mortality factors.Influenza and other respiratory viruses · 2023Article
- Clinical characteristics and outcomes of immunocompromised patients with severe community-acquired pneumonia: A single-center retrospective cohort study.Frontiers in public health · 2023Observational
- Sex differences in COVID-19 mortality risk in patients on kidney function replacement therapy.Scientific reports · 2022Article
- Article
- Impact of early therapeutic modality on 28-day mortality in immunocompromised patients with opportunistic pulmonary infections: a multicenter retrospective study.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo explore disease severity and risk factors for 30-day mortality of adult immunocompromised (IC) patients hospitalized with influenza-related pneumonia (Flu-p).
methodA total of 122 IC and 1191 immunocompetent patients hospitalized with Flu-p from January 2012 to December 2018 were recruited retrospectively from five teaching hospitals in China.
resultsAfter controlling for confounders, multivariate logistic regression analysis showed that immunosuppression was associated with increased risks for invasive ventilation [odds ratio: (OR) 2.475, 95% confidence interval (CI): 1.511-4.053, p < 0.001], admittance to the intensive care unit (OR: 3.247, 95% CI 2.064-5.106, p < 0.001), and 30-day mortality (OR: 3.206, 95% CI 1.926-5.335, p < 0.001) in patients with Flu-p. Another multivariate logistic regression model revealed that baseline lymphocyte counts (OR: 0.993, 95% CI 0.990-0.996, p < 0.001), coinfection (OR: 5.450, 95% CI 1.638-18.167, p = 0.006), early neuraminidase inhibitor therapy (OR 0.401, 95% CI 0.127-0.878, p = 0.001), and systemic corticosteroid use at admission (OR: 6.414, 95% CI 1.348-30.512, p = 0.020) were independently related to 30-day mortality in IC patients with Flu-p. Based on analysis of the receiver operating characteristic curve (ROC), the optimal cutoff for lymphocyte counts was 0.6 × 10
conclusionsIC conditions are associated with more severe outcomes in patients with Flu-p. The predictors for mortality that we identified may be valuable for the management of Flu-p among IC patients.
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