ArticleBMC microbiology2021
Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria.
Article in BMC microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Whole-Genome Sequencing of Invasive Neonatal Escherichia coli From Uppsala County, Sweden.The Journal of infectious diseases · 2024Article
- The microbial landscape of colorectal cancer.Nature reviews. Microbiology · 2024Review
- Intratumoral presence of the genotoxic gut bacteria pksBritish journal of cancer · 2024Article
- Enrichment of colibactin-associated mutational signatures in unexplained colorectal polyposis patients.BMC cancer · 2024Article
- Does month of birth influence colorectal cancer prognosis?Langenbeck's archives of surgery · 2023Observational
- Maternal and Child Health, Non-Communicable Diseases and Metabolites.Metabolites · 2023Review
- Screening method toward ClbP-specific inhibitors.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2023Article
- Inulin impacts tumorigenesis promotion by colibactin-producingFrontiers in microbiology · 2023Article
- Prevalence of pks + bacteria and enterotoxigenic Bacteroides fragilis in patients with colorectal cancer.Gut pathogens · 2022Article
- Characterization of Escherichia coli harboring colibactin genes (clb) isolated from beef production and processing systems.Scientific reports · 2022Article
- Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan.Cancer science · 2022Article
- A Probiotic Friend.mSphere · 2021Article
- Microbiota-derived small molecule genotoxins: host interactions and ecological impact in the gut ecosystem.Gut microbesReview
- Induction of DNA Damage in Mouse Colorectum by Administration of Colibactin-producingIn vivo (Athens, Greece)Article
- Review
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Escherichia coli strain that is known to produce the genotoxic secondary metabolite colibactin is linked to colorectal oncogenesis. Therefore, understanding the properties of such colibactin-positive E. coli and the molecular mechanism of oncogenesis by colibactin may provide us with opportunities for early diagnosis or prevention of colorectal oncogenesis. While there have been major advances in the characterization of colibactin-positive E. coli and the toxin it produces, the infection route of the clb + strain remains poorly characterized.
resultsWe examined infants and their treatments during and post-birth periods to examine potential transmission of colibactin-positive E. coli to infants. Here, analysis of fecal samples of infants over the first month of birth for the presence of a colibactin biosynthetic gene revealed that the bacterium may be transmitted from mother to infant through intimate contacts, such as natural childbirth and breastfeeding, but not through food intake.
conclusionsOur finding suggests that transmission of colibactin-positive E. coli appears to be occurring at the very early stage of life of the newborn and hints at the possibility of developing early preventive measures against colorectal cancer.
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