Evidence map›Paper›PMID 34428947›Full record

ArticleJournal of the Royal Society, Interface2021

Go with the FLOW: visualizing spatiotemporal dynamics in optical widefield calcium imaging.

Nathaniel J Linden, Dennis R Tabuena, Nicholas A Steinmetz, William J Moody, Steven L Brunton, Bingni W Brunton

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Mesoscale calcium imagingFrontiers in neuroscience · 2023
    Review
  8. Review
  9. Article
  10. Challenges in dynamic mode decomposition.Journal of the Royal Society, Interface · 2021
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nathaniel J LindenDepartment of Bioengineering, University of Washington, Seattle, WA 98195-0005, USA.
Dennis R TabuenaDepartment of Biology, University of Washington, Seattle, WA 98195-0005, USA.
Nicholas A SteinmetzDepartment of Biological Structure, University of Washington, Seattle, WA 98195-0005, USA.
William J MoodyDepartment of Biology, University of Washington, Seattle, WA 98195-0005, USA.
Steven L BruntonDepartment of Mechanical Engineering, University of Washington, Seattle, WA 98195-0005, USA.
Bingni W BruntonDepartment of Biology, University of Washington, Seattle, WA 98195-0005, USA.

Funding

Reimbursement request for attending the Meeting of the Jointly Sponsored Institutional Predoctoral Training in the Neurosciences T32 Program Directors in Baltimore, MD on 2/19/19T32NS099578 · NINDS · UNIVERSITY OF WASHINGTON · PI SULLIVAN, JANE M, WONG, RACHEL O · 2016 to 2020
$1.4M
NINDS NIH HHS T32 NS099578
6 · The paper itself

Abstract

Widefield calcium imaging has recently emerged as a powerful experimental technique to record coordinated large-scale brain activity. These measurements present a unique opportunity to characterize spatiotemporally coherent structures that underlie neural activity across many regions of the brain. In this work, we leverage analytic techniques from fluid dynamics to develop a visualization framework that highlights features of flow across the cortex, mapping wavefronts that may be correlated with behavioural events. First, we transform the time series of widefield calcium images into time-varying vector fields using optic flow. Next, we extract concise diagrams summarizing the dynamics, which we refer to as

Indexed as

BrainCalciumAnimalsMiceCalciumcoherent structurescomputational neurosciencedynamical systemsfinite-time Lyapunov exponentswidefield calcium imaging

Identifiers

PMID34428947
PMCPMC8385384

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.