ArticleJournal of the Royal Society, Interface2021
Antibiotic treatment protocols revisited: the challenges of a conclusive assessment by mathematical modelling.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- The impact of treatment strategies on the epidemiological dynamics of plasmid-conferred antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Modelling the implementation of narrow versus broader spectrum antibiotics in the empiric treatment of E. coli bacteraemia.Scientific reports · 2024Article
- An agent-based model on antimicrobial de-escalation in intensive care units: Implications on clinical trial design.PloS one · 2024Article
- Linking within- and between-host scales for understanding the evolutionary dynamics of quantitative antimicrobial resistance.Journal of mathematical biology · 2023Article
- Controlling the Mean Time to Extinction in Populations of Bacteria.Entropy (Basel, Switzerland) · 2023Article
- Sequential antibiotic therapy in the laboratory and in the patient.Journal of the Royal Society, Interface · 2023Article
- A Refunding Scheme to Incentivize Narrow-Spectrum Antibiotic Development.Bulletin of mathematical biology · 2022Article
- Comparing optimization criteria in antibiotic allocation protocols.Royal Society open science · 2022Article
- Article
- Epidemiological and evolutionary consequences of periodicity in treatment coverage.Proceedings. Biological sciences · 2021Article
- Treatment timing shifts the benefits of short and long antibiotic treatment over infection.Evolution, medicine, and public health · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hospital-acquired bacterial infections lead to prolonged hospital stays and increased mortality. The problem is exacerbated by antibiotic-resistant strains that delay or impede effective treatment. To ensure successful therapy and to manage antibiotic resistance, treatment protocols that draw on several different antibiotics might be used. This includes the administration of drug cocktails to individual patients (combination therapy) but also the random assignment of drugs to different patients (mixing) and a regular switch in the default drug used in the hospital from drug
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Registered trials
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