Trial reportCirculation research2021
Epigenetic Age Acceleration Reflects Long-Term Cardiovascular Health.
Abstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the association between cardiovascular health determined by life's essential 8 and risk of mortality and major non-communicable diseases.Frontiers in cardiovascular medicine · 2025Pooled it
- Repurposing effect of cardiovascular-metabolic drug to increase lifespan: a systematic review of animal studies and current clinical trial progress.Frontiers in pharmacology · 2024Pooled it
- Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study.Clinical epigenetics · 2023Pooled it
- Epigenetic Age Acceleration and Cardiometabolic Biomarkers in Response to Weight-Loss Dietary Interventions Among Obese Individuals: The MACRO Trial.Aging cell · 2025Trial
- Epigenetic aging and DNA methylation biomarker changes following ketamine treatment in patients with MDD and PTSD: a pilot study.Translational psychiatry · 2025Trial
- Impact of folic acid supplementation on the epigenetic profile in healthy unfortified individuals - a randomized intervention trial.Epigenetics · 2024Trial
- Article
- Assessing differences in epigenetic aging markers between sexual or gender minority and straight cisgender adults using the Coronary Artery Risk Development in Young Adults cohort.Social science & medicine (1982) · 2026Article
- Epigenetic signatures of cardiometabolic risk in men: accelerated aging and differential methylation replicated across cohorts.Clinical epigenetics · 2026Article
- The role of epigenetic age acceleration and social disadvantage in cardiometabolic health in southeast Louisiana women.Clinical epigenetics · 2026Article
- Epigenetic regulation in atherosclerosis and its therapeutic potential.Nature reviews. Cardiology · 2026Review
- [Application of biological age for cardiovascular risk prediction in a community-based Chinese cohort].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Therapeutic implications of epigenetic alterations in burns: a new frontier in burn medicine.Clinical science (London, England : 1979) · 2026Review
- Ten-year trajectory of Life's Essential 8 and aortic valve calcification.American journal of preventive cardiology · 2026Article
- Association of accelerated phenotypic aging, lifestyle and genetic risk with progression of cardiometabolic multimorbidity: a multi-state model analysis.GeroScience · 2026Article
- Vascular Aging.Circulation · 2026Review
- Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults.JAMA network open · 2026Article
- Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults.Clinical epigenetics · 2026Article
- Epigenetic aging markers in the association between frailty and mortality among U.S. adults.BMC medicine · 2026Article
- Bidirectional associations between biological aging, cardiovascular health, and cardiovascular risk: findings from the INSPIRE-T lifespan cohort.GeroScience · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Brian T JoyceCenter for Global Oncology, Institute for Global Health (B.T.J., T.G., Y.Z., D.N., L.H.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-5271-6161
Tao GaoCenter for Global Oncology, Institute for Global Health (B.T.J., T.G., Y.Z., D.N., L.H.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
Yinan ZhengCenter for Global Oncology, Institute for Global Health (B.T.J., T.G., Y.Z., D.N., L.H.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-2006-7320
Jiantao MaThe Framingham Heart Study, Framingham, MA; (J.M., S.-J.H., D.L.).
Shih-Jen HwangThe Framingham Heart Study, Framingham, MA; (J.M., S.-J.H., D.L.).ORCID 0000-0002-2129-5704
Lei LiuDivision of Biostatistics, Washington University, St. Louis, MO (L.L.).
Drew NanniniCenter for Global Oncology, Institute for Global Health (B.T.J., T.G., Y.Z., D.N., L.H.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
Steve HorvathDepartment of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA (S.H., A.T.L.).
Ake T LuDepartment of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA (S.H., A.T.L.).ORCID 0000-0002-2866-7961
Norrina Bai AllenDepartment of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health (D.R.J., M.G.), University of Minnesota, Minneapolis.ORCID 0000-0002-7232-0543
Myron GrossDivision of Epidemiology and Community Health, School of Public Health (D.R.J., M.G.), University of Minnesota, Minneapolis.
Amy KrefmanDepartment of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
Hongyan NingDepartment of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
Kiang LiuDepartment of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0001-7357-1507
Cora E LewisDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham (C.E.L., J.M.S.).ORCID 0000-0002-2301-5796
Pamela J SchreinerSchool of Public Health (P.J.S.), University of Minnesota, Minneapolis.ORCID 0000-0002-9920-6257
Stephen SidneyDivision of Research, Kaiser Permanente, Oakland, CA (S.S.).
James M ShikanyDivision of Preventive Medicine, School of Medicine, University of Alabama at Birmingham (C.E.L., J.M.S.).ORCID 0000-0002-2424-9308
Daniel LevyThe Framingham Heart Study, Framingham, MA; (J.M., S.-J.H., D.L.).ORCID 0000-0003-1843-8724
Philip GreenlandDepartment of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0002-6327-2439
Lifang Hou *Center for Global Oncology, Institute for Global Health (B.T.J., T.G., Y.Z., D.N., L.H.), Feinberg School of Medicine, Northwestern University, Chicago, IL.
Donald Lloyd-Jones *Department of Preventive Medicine (B.T.J., T.G., Y.Z., D.N., N.B.A., A.K., H.N., K.L., P.G., L.H., D.L.-J.), Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0003-0847-6110
Funding
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ANANDA BASU · 2013 to 2026
$19.5MValidation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4MDietary factors, biomarkers, metabolic pathways related to non-alcoholic fatty liver diseaseK22HL135075 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MA, JIANTAO · 2019 to 2021
$747kHigh Dimensional Mediation Analysis for DNA Methylation Markers Mediating Cardiovascular Health Metrics and Cardiovascular DiseasesR21AG063370 · NIA · WASHINGTON UNIVERSITY · PI HOU, LIFANG, LIU, LEI · 2019 to 2020
$447kNHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS K22 HL135075NIA NIH HHS R21 AG063370NIA NIH HHS U01 AG060908NIDDK NIH HHS P30 DK079626
Abstract
[Figure: see text].
Indexed as
Epigenesis, GeneticAdolescentAdultAgedAgingCardiovascular DiseasesDNA MethylationFemaleHumansMaleblood pressurecardiovascular diseasesDNA methylationhumansyoung adult
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.