ArticleCirculation. Heart failure2021
Characterizing Sex Differences in Physical Frailty Phenotypes in Heart Failure.
Article in Circulation. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- Sex Differences in Efficacy of Multidomain Rehabilitation Among Older Adults With Acute HF: The REHAB-HF Trial.JACC. Heart failure · 2025Trial
- Exploring Associations Between Social Risk Factors and Physical Frailty in Heart Failure: A Cross-Sectional Analysis.Journal of cardiac failure - intersections · 2026Article
- Response to "Comments on: A simplified frailty assessment using three objective measures predicts mid-term outcomes after cardiac surgery".General thoracic and cardiovascular surgery · 2026Article
- A simplified frailty assessment using three objective measures predicts mid-term outcomes after cardiac surgery.General thoracic and cardiovascular surgery · 2026Observational
- Characterising Multimorbidity in Adults With Heart Failure: A Latent Class Analysis.Heart, lung & circulation · 2026Article
- Prevalence and associated factors of frailty in hospitalized elderly patients with heart failure.Frontiers in cardiovascular medicine · 2026Article
- Clinical Pharmacology of Heart Failure in Frailty.European cardiology · 2026Review
- Understanding Frailty in Cardiac Rehabilitation: A Scoping Review of Prevalence, Measurement, Sex and Gender Considerations, and Barriers to Completion.Journal of clinical medicine · 2025Review
- Background and design of the Physical Frailty and Symptom Monitoring and Management Behaviors in Heart Failure (PRISM-HF) study: A mixed methods study.International journal of nursing studies advances · 2025Review
- Plasma proteomic biomarkers of physical frailty in heart failure: a propensity score matched discovery-based pilot study.BMC cardiovascular disorders · 2025Article
- Sex differences in the impact of frailty on patients with heart failure: A retrospective cohort study.ESC heart failure · 2024Article
- Which of these symptom trajectories is not like the other?European journal of cardiovascular nursing · 2024Article
- Assessment of Frailty Among Older Adults in the Physical Activity Daily Trial.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2024Observational
- Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation.Current heart failure reports · 2024Review
- Sympathetic dysfunction is associated with worse fatigue and early and subtle symptoms in heart failure: an exploratory sex-stratified analysis.European journal of cardiovascular nursing · 2024Article
- Sex-related similarities and differences in responses to heart failure therapies.Nature reviews. Cardiology · 2024Review
- Frailty, Sarcopenia, Cachexia, and Malnutrition in Heart Failure.Korean circulation journal · 2024Review
- ALM/BMI: A Clinically Superior Index for Identifying Skeletal Muscle Dysfunction in Patients With Heart Failure.Journal of the American Heart Association · 2024Article
- Hemoglobin is an independent predictor of improvement exercise tolerance in male patients with non-ischemic cardiomyopathy.Heart and vessels · 2024Article
- Impact of Frailty on Heart Failure Prognosis: Is Sex Relevant?Current heart failure reports · 2024Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAlthough women with heart failure (HF) are potentially more likely to be physically frail compared with men with HF, the underlying contributors to this sex difference are poorly understood. The purpose of this study was to characterize sex differences in physical frailty phenotypes in HF.
methodsWe prospectively enrolled adults with class I-IV HF. Physical frailty was measured with the frailty phenotype criteria. Symptoms of dyspnea, sleep-related impairment, pain interference, depression, and anxiety were assessed. Body composition was measured using dual-energy x-ray absorptiometry. Simple comparative statistics and stepwise regression modeling were used.
resultsThe average age of the sample (n=115) was 63.6±15.7 years, 49% were women, and 73% had nonischemic cause. Forty-three percent of the sample was physically frail. Women had a 4.6 times greater odds of being physically frail compared with men, adjusting for covariates (odds ratio=4.63 [95% CI, 1.81-11.84],
conclusionsWomen are significantly more likely to be physically frail compared with men in HF. Physical frailty in both women and men is characterized by comorbidities and worse symptoms; physical frailty in men is characterized by worse physiological characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.