Evidence map›Paper›PMID 34428395›Full record

ArticleDevelopmental cell2021

Who watches the watchmen? RNAi pathway-derived ribosomal small RNAs burgeon in absence of piRNAs.

Navin B Ramakrishna, Eric A Miska

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. piRNAs safeguard splicing and RNA fidelity during heat shock.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Navin B RamakrishnaWellcome/CRUK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge, UK.
Eric A MiskaWellcome/CRUK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, UK; Department of Genetics, University of Cambridge, Downing Street, Cambridge, UK; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. Electronic address: eam29@cam.ac.uk.
University of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Instead of causing immediate sterility, loss of the C. elegans PIWI protein PRG-1 leads to accumulated infertility after tens of generations. In this issue of Developmental Cell, Wahba et al. show that this correlates with aberrant RNA interference pathway-dependent feed forward amplification of ribosomal siRNAs-the proposed accumulative sterility factor.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsArgonaute ProteinsRNA InterferenceRNA, RibosomalRNA, Small InterferingArgonaute ProteinsCaenorhabditis elegans ProteinsPRG-1 protein, C elegansRNA, RibosomalRNA, Small Interfering

Identifiers

PMID34428395
OpenAlexW3196240385

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.