ArticleCancer reports (Hoboken, N.J.)2022
Out-of-pocket costs associated with head and neck cancer treatment.
Article in Cancer reports (Hoboken, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Measuring financial toxicity in head and neck cancer: a systematic review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2024Pooled it
- Review
- Future Inpatient Cost Burden of Laryngeal Cancer in Romania: Aging, Residence, and Prevention Scenarios in a Nationwide Ecological Study.Healthcare (Basel, Switzerland) · 2026Article
- Financial Toxicity in Selected Head and Neck Cancers: A Scoping Review of Measurement, Burden, and Outcomes.Cancers · 2026Review
- Nanomedicine as an opportunity for equity achievements through cost-reduction in public healthcare for head and neck cancer treatment in Brazil.BMC health services research · 2026Article
- Trends in Treatment Choice for Early Glottic Cancer.Journal of clinical medicine · 2025Article
- Choice of Adjuvant Radiotherapy Facility in Sinonasal Squamous Cell Carcinoma.The Laryngoscope · 2025Article
- Financial Burden of Dental Care Among Patients With Head and Neck Cancer.JAMA otolaryngology-- head & neck surgery · 2024Article
- Medicare dental coverage for patients with head and neck cancer: An opportunity in need of advocates.Oral oncology · 2024Article
- Organization of head and neck cancer rehabilitation care: a national survey among healthcare professionals in Dutch head and neck cancer centers.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Factors associated with oral hygiene compliance in patients treated with radiation therapy for head and neck cancer.Journal of the American Dental Association (1939) · 2024Observational
- Financial Toxicity and Out-of-Pocket Costs for Patients with Head and Neck Cancer.Current oncology (Toronto, Ont.) · 2023Article
- Mendelian randomization eradicates the causal relationship between educational attainment, household income, and oropharyngeal cancer.Frontiers in oncology · 2023Article
- Association of Household Income at Diagnosis With Financial Toxicity, Health Utility, and Survival in Patients With Head and Neck Cancer.JAMA otolaryngology-- head & neck surgery · 2023Article
- Out-of-pocket costs associated with head and neck cancer treatment.Cancer reports (Hoboken, N.J.) · 2022Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOut-of-pocket costs (OOPC) associated with treatment have significant implications on quality of life and survival in cancer patients. Head and neck cancer patients face unique treatment-related challenges, but to date OOPC have been understudied in this population.
aimsThis study aims to identify and measure OOPC for patients with head and neck cancer (HNC) in Ontario.
methodsHNC patients between 2015 and 2018 at Princess Margaret Cancer Centre in Toronto were recruited. Participants completed OOPC questionnaires and lost income questions during radiation, post-surgery, and 3, 6, 12, and 24 months after completion of treatment. Associations between OOPC and treatment modality and disease site were tested with multivariable hurdle regression.
resultsA total of 1545 questionnaires were completed by 657 patients. Median estimated OOPC for the total duration of treatment for participants undergoing chemoradiation was $1452 [$0-14 616], for surgery with adjuvant radiation or chemoradiation (C/RT) was $1626, for radiation therapy alone was $635, and for surgery alone was $360. The major expenses for participants at the mid-treatment time-point was travel (mean $424, standard error of the mean [SEM] $34) and meals, parking, and accommodations (mean $617, SEM $67). In multivariable analysis, chemoradiation, surgery with C/RT, and radiation were associated with significantly higher OOPC than surgery alone during treatment (791% higher, p < .001; 539% higher, p < .001; 370% higher, p < .001 respectively) among patients with non-zero OOPC. Participants with non-zero OOPC in the laryngeal cancer group paid 49% lower OOPC than those with oropharyngeal cancers in adjusted analysis (p = .025).
conclusionsPatients undergoing treatment for HNC pay significant OOPC. These costs are highest during treatment and gradually decrease over time. OOPC vary by patient demographics, clinical factors, and, in particular, treatment modality.
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