ArticlePloS one2021
Development of a standardized MRI protocol for pancreas assessment in humans.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Quantifying Pancreatic Fat Using a Free-Breathing Acquisition in Adults With Obesity Undergoing Diet-Induced Weight Loss-Results From the LION Study.NMR in biomedicine · 2026Trial
- Pancreas Size and Fat Content Increase during Pregnancy and Correlate with Glycemic Control.American journal of perinatology · 2026Article
- Article
- Diagnostic Performance of Transabdominal Ultrasonography for Pancreatic Fat in Adults with Metabolic Risk Factors for NAFPD: Comparison with a Study-Defined Two-Echo MRI Index.Diagnostics (Basel, Switzerland) · 2026Article
- Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus.Nature reviews. Gastroenterology & hepatology · 2026Review
- Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging.Journal of magnetic resonance imaging : JMRI · 2026Review
- Lifespan Pancreas Morphology for Control Versus Type 2 Diabetes Using AI on Largescale Clinical Imaging.Clinical anatomy (New York, N.Y.) · 2026Article
- Use of Teplizumab to Modulate Stage 2 Type 1 Diabetes in Two Individuals With Autoimmune Polyendocrine Syndrome 1.Diabetes care · 2026Article
- Article
- Toward diffusion MRI in the diagnosis and treatment of pancreatic cancer.Medical oncology (Northwood, London, England) · 2025Review
- Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes.Diabetes care · 2024Article
- Consensus Minimum MRI Protocol for the Child With Acute Recurrent or Chronic Pancreatitis.AJR. American journal of roentgenology · 2024Article
- Longitudinal MRI Shows Progressive Decline in Pancreas Size and Altered Pancreas Shape in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2023Article
- Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas.Diabetes care · 2023Article
- Article
- Pancreas Imaging of Children with Type 1 Diabetes Reveals New Patterns and Correlations with Pancreatic Functions.Pediatric diabetes · 2023Article
- Deep learning-based pancreas volume assessment in individuals with type 1 diabetes.BMC medical imaging · 2022Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Calibrated phantoms with known MRI properties were imaged at five sites with differing MRI hardware and software to develop a harmonized MRI imaging protocol. Subsequently, five healthy volunteers underwent MRI at four sites using the harmonized protocol to assess pancreas size, shape, apparent diffusion coefficient (ADC), longitudinal relaxation time (T1), magnetization transfer ratio (MTR), and pancreas and hepatic fat fraction. Following harmonization, pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time were reproducible, with coefficients of variation less than 10%. In contrast, non-standardized image processing led to greater variation in MRI measurements. By using a standardized MRI image acquisition and processing protocol, quantitative MRI of the pancreas performed at multiple locations can be incorporated into clinical trials comparing pancreas imaging measures and metabolic state in individuals with type 1 or type 2 diabetes.
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Registered trials
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