Evidence map›Paper›PMID 34428087›Full record

ArticleThe neuroradiology journal2022

Diagnostic utility of parasagittal measurements of tonsillar herniation in Chiari I malformation.

Seyed Amir Ebrahimzadeh, Francis Loth, Alaaddin Ibrahimy, Blaise Simplice Talla Nwotchouang, Rafeeque A Bhadelia

Open access · greenAbstract read
In one paragraph

Article in The neuroradiology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Seyed Amir EbrahimzadehDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA.ORCID https://orcid.org/0000-0003-4927-8444
Francis LothDepartment of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, USA.
Alaaddin IbrahimyDepartment of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, USA.
Blaise Simplice Talla NwotchouangDepartment of Mechanical Engineering, Conquer Chiari Research Center, The University of Akron, USA.
Rafeeque A BhadeliaDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA.
University of Akron · USBeth Israel Deaconess Medical Center · US

Funding

Novel MR Image Processing as an Objective Diagnostic Test for Chiari MalformationR15NS109957 · NINDS · UNIVERSITY OF AKRON · PI ALLEN, PHILIP A. · 2019 to 2019
$469k
NINDS NIH HHS R15 NS109957
6 · The paper itself

Abstract

background and purposeAlthough the cerebellar tonsils are parasagittal structures, the extent of tonsillar herniation (ETH) in Chiari I malformation (CMI) is currently measured in the midsagittal plane. We measured the ETH of each cerebellar tonsil in the parasagittal plane and assessed their diagnostic utility by comparing them to the midsagittal ETH measurements in predicting cough-associated headache (CAH), an indicator of clinically significant disease in CMI.

methodsEighty-five CMI patients with 3D-MPRAGE images were included. Neurosurgeons determined the presence of CAH. Sagittal images were used to measure ETH in the midsagittal (MS_ETH) and parasagittal planes (by locating tonsillar tips on each side on reformatted coronal images). Given the parasagittal ETH (PS_ETH) asymmetry in the majority of cases, they were considered Smaller_PS_ETH or Larger_PS_ETH. The accuracy of ETH measurements was assessed by the receiver operating characteristic (ROC) curve.

resultsOf 85 patients, 46 reported CAH. ROC analysis showed an area under the curve (AUC) of 0.78 for Smaller_PS_ETH significantly better than 0.65 for MS-ETH in predicting CAH (

conclusionsDiagnostic utility of ETH measurements in detecting clinically significant CMI can be improved by parasagittal measurements of the cerebellar tonsillar herniation.

Indexed as

Arnold-Chiari MalformationEncephaloceleHumansImaging, Three-DimensionalMagnetic Resonance ImagingSensitivity and SpecificityChiari 1 malformationcoughheadacheMRIparasagittal

Identifiers

PMID34428087
PMCPMC9130617
OpenAlexW3194577254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.