Evidence map›Paper›PMID 34427992›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Ni-Catalyzed Arylbenzylation of Alkenylarenes: Kinetic Studies Reveal Autocatalysis by ZnX

Roshan K Dhungana, Rishi R Sapkota, Laura M Wickham, Doleshwar Niroula, Bijay Shrestha, Ramesh Giri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Roshan K DhunganaDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Rishi R SapkotaDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Laura M WickhamDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Doleshwar NiroulaDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.
Bijay ShresthaCurrent address: Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA.
Ramesh GiriDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, 16802, USA.ORCID 0000-0002-8993-9131

Funding

New Directions in Alkene Difunctionalization ReactionsR35GM133438 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Ramesh Giri · 2019 to 2026
$3.2M
NIGMS NIH HHS R35 GM133438NIGMS NIH HHS R35GM133438
6 · The paper itself

Abstract

We report a Ni-catalyzed regioselective arylbenzylation of alkenylarenes with benzyl halides and arylzinc reagents. The reaction furnishes differently substituted 1,1,3-triarylpropyl structures that are reminiscent of the cores of oligoresveratrol natural products. The reaction is also compatible for the coupling of internal alkenes, secondary benzyl halides and variously substituted arylzinc reagents. Kinetic studies reveal that the reaction proceeds with a rate-limiting single-electron-transfer process and is autocatalyzed by in-situ-generated ZnX

Indexed as

AlkenesBenzyl CompoundsBromidesCatalysisKineticsNickelZinc CompoundsAlkenesbenzyl bromideBenzyl CompoundsBromidesNickelzinc bromideZinc Compoundsalkenylarenesarylbenzylationdifunctionalizationnickel catalysistriarylalkyl groups

Identifiers

PMID34427992
PMCPMC8490319

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.