Evidence map›Paper›PMID 34427926›Full record

SynthesisClinical cardiology2021

Cost-minimization analysis of a wearable cardioverter defibrillator in adult patients undergoing ICD explant procedures: Clinical and economic implications.

Giuseppe Boriani, Lorenzo Giovanni Mantovani, Paolo Angelo Cortesi, Roberto De Ponti, Antonio D'Onofrio, Giuseppe Arena, Antonio Curnis, Giovanni Forleo, Federico Guerra, Maurizio Porcu and 2 more

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Clinical cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. A review on wearable cardioverter-defibrillators in clinical practice for sudden cardiac death prevention and heart failure management.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Challenging the status quo: a scoping review of value-based care models in cardiology and electrophysiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 12 institutions in 1 country.

Giuseppe BorianiCardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Italy.ORCID https://orcid.org/0000-0002-9820-4815
Lorenzo Giovanni MantovaniResearch Centre on Public Health (CESP), University of Milano-Bicocca, Monza, Italy.ORCID https://orcid.org/0000-0003-3866-8199
Paolo Angelo CortesiResearch Centre on Public Health (CESP), University of Milano-Bicocca, Monza, Italy.ORCID https://orcid.org/0000-0002-5353-3957
Roberto De PontiDepartment of Heart and Vessels, Ospedale di Circolo-University of Insubria, Varese, Italy.ORCID https://orcid.org/0000-0003-3278-1721
Antonio D'OnofrioCardiology Division - Electrophysiology Department - AORN dei Colli - Ospedale Monaldi, Napoli, Italy.
Giuseppe ArenaCardiology Department, Azienda Usl Toscana Nord Ovest, Massa Carrara, Italy.ORCID https://orcid.org/0000-0002-0266-6493
Antonio CurnisCardiology Department, Presidio Ospedaliero di Brescia, ASST Spedali Civili, Brescia, Italy.
Giovanni ForleoCardiology Department, Electrophysiology and Arrhtymology Division, Ospedale Luigi Sacco - Polo Universitario, Milan, Italy.ORCID https://orcid.org/0000-0001-8895-8915
Federico GuerraCardiology and Arrhytmology Clinic, Azienda Ospedaliero Universitaria Ospedali Riuniti, Ancona, Italy.ORCID https://orcid.org/0000-0001-5394-1312
Maurizio PorcuCardiology Department, Azienda Ospedaliera "G. Brotzu", Cagliari, Italy.ORCID https://orcid.org/0000-0003-0633-1487
Giuseppe SgaritoCardiology Department, Electrophysiology and Arrhtymology Division, A.R.N.A.S. Ospedali Civico, Palermo, Italy.
Giovanni Luca BottoCardiology - Electrophysiology Division, Department of Medicine, Ospedale di Circolo Rho, Ospedale Salvini Garbagnate M.se, ASST Rhodense, Milan, Italy.ORCID https://orcid.org/0000-0002-8049-7517
Azienda di Rilievo Nazionale ed Alta Specializzazione · ITAzienda Ospedaliera G. Brotzu · ITAzienda Ospedaliero Universitaria Ospedali Riuniti · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITAzienda Usl Toscana Centro · ITAziende Socio Sanitaria Territoriale RhodenseLuigi Sacco Hospital · ITMultiMedica · ITOspedale Monaldi · ITUniversity of Insubria · ITUniversity of Milano-Bicocca · ITUniversity of Modena and Reggio Emilia · IT

Funding

ZOLL Medical Corporation
6 · The paper itself

Abstract

aimsPatients with permanently increased risk of sudden cardiac death (SCD) can be protected by implantable cardioverter defibrillators (ICD). If an ICD must be removed due to infection, for example, immediate reimplantation might not be possible or indicated. The wearable cardioverter defibrillator (WCD) is an established, safe and effective solution to protect patients from SCD during this high-risk bridging period. Very few economic evaluations on WCD use are currently available.

methodsWe conducted a systematic review to evaluate the available evidence of WCD in patients undergoing ICD explant/lead extraction. Additionally, a decision model was developed to compare use and costs of the WCD with standard therapy (in-hospital stay). For this purpose, a cost-minimization analysis was conducted, and complemented by a one-way sensitivity analysis.

resultsIn the base case scenario, the WCD was less expensive compared to standard therapy. The cost-minimization analysis showed a cost reduction of €1782 per patient using the WCD. If costs of standard care were changed, cost savings associated with the WCD varied from €3500 to €0, assuming costs for standard care of €6800 to €3600.

conclusionAfter ICD explantation, patients can be safely and effectively protected from SCD after hospital discharge through WCD utilization. Furthermore, the use of a WCD for this patient group is cost saving when compared to standard therapy.

Indexed as

Defibrillators, ImplantableWearable Electronic DevicesAdultCost-Benefit AnalysisDeath, Sudden, CardiacDefibrillatorsElectric CountershockHumanscost-minimization analysishealth technology assessmentICD explantsudden cardiac deathventricular arrhythmiawearable cardioverter defibrillator

Identifiers

PMID34427926
PMCPMC8571546
OpenAlexW3195672609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.