ReviewHormones (Athens, Greece)2021
Subclinical thyroid dysfunction and major depressive disorder.
Review in Hormones (Athens, Greece), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Association between thyroid hormone levels in the acute stage of stroke and risk of poststroke depression: A meta-analysis.Brain and behavior · 2024Pooled it
- Prevalence and Clinical Correlates of Suicide Attempts Among Young Patients With Major Depressive Disorder With Subclinical Hypothyroidism: A Cross-Sectional Study.Brain and behavior · 2026Article
- The Association of Thyroid Function on Cognition and Neuropsychiatric Symptoms in Patients with Cognitive Impairment.Neuropsychiatric disease and treatment · 2026Article
- Influence of Preexisting Psychiatric Morbidity on Liothyronine Use in Hypothyroidism: A Swedish Nationwide Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Physical Activity, Nutritional Behaviours and Depressive Symptoms in Women with Hashimoto's Disease.Healthcare (Basel, Switzerland) · 2025Article
- Exploring Gender Differences in the Relationship Between Thyroid Function and Aggressive and Impulsive Behaviors in Patients with Major Depressive Disorder.Neuropsychiatric disease and treatment · 2025Article
- Metabolomic Changes in Major Depressive Disorder Adolescent Females with or without Suicide Attempts.Current neuropharmacology · 2025Article
- Association between vitamin A intake and depression among patients with heart failure.ESC heart failure · 2024Article
- Prevalence and risk factors for subclinical hypothyroidism in older patients with major depressive disorder.BMC geriatrics · 2024Article
- Association of four metalloids in the serum and urine of individuals with major depressive disorders: a case-control study.Frontiers in psychiatry · 2024Article
- The Association between Depression, Anxiety, and Thyroid Disease: A UK Biobank Prospective Cohort Study.Depression and anxiety · 2024Article
- Exploring the Relationship between Mood Disorders and Coexisting Health Conditions: The Focus on Nutraceuticals.Brain sciences · 2023Review
- Exploring the Genetic Link Between Thyroid Dysfunction and Common Psychiatric Disorders: A Specific Hormonal or a General Autoimmune Comorbidity.Thyroid : official journal of the American Thyroid Association · 2023Article
- Gray matter reduction is associated with cognitive dysfunction in depressed patients comorbid with subclinical hypothyroidism.Frontiers in aging neuroscience · 2023Article
- Prevalence and Factors Associated with Subclinical Hypothyroidism in Major Depressive Disorder Patients with Dyslipidemia.Neuropsychiatric disease and treatment · 2023Article
- Hypothyroidism and Depression: A Narrative Review.Cureus · 2022Review
- Depression and Autoimmune Hypothyroidism-Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines-A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Association of Subclinical Hypothyroidism With Anxiety Symptom in Young First-Episode and Drug-Naïve Patients With Major Depressive Disorder.Frontiers in psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis review attempts to investigate the link between subclinical thyroid dysfunction (SCH) and major depressive disorder (MDD). It has been speculated that SCH may be related to MDD through an autoimmune mechanism.
methodsA comprehensive literature search was conducted in the PubMed database for relevant research and review articles.
resultsThere appears to be an association between an autoimmune mechanism, possibly involving the thyroid gland, and depressive disorders, but the available evidence is so far inconclusive.
conclusionLifetime prevalence of depression is significantly higher in patients with SCH, a finding reflecting a possible effect of SCH in lowering the threshold for the emergence of MDD. The relationship between SCH and MDD is, however, not clear, with large and well-designed studies investigating possible links between reference-range thyroid hormone levels and MDD having as yet found no relation between the two.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.