ArticleBrain imaging and behavior2022
Brain functional specialization and cooperation in Parkinson's disease.
Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Pallidal and subthalamic stimulations modulate inter-hemispheric interaction and asymmetry in Parkinson's disease.Molecular psychiatry · 2026Article
- Aberrant Functional Lateralization and Interhemispheric Synergy in High Myopia: Insights From Neurotransmitter Distribution Signatures and Machine Learning Classification.Investigative ophthalmology & visual science · 2026Article
- Altered Functional Specialization and Interhemispheric Coordination in Rhegmatogenous Retinal Detachment: Associations With Gene Expression, Neurotransmitter Receptor Distribution, and SVM-SHAP ClassificationCNS neuroscience & therapeutics · 2026Article
- The phase average wavelength of alpha rhythm in EEG signals of patients with Parkinson's disease combined with cognitive impairment.PloS one · 2026Article
- A connectome-based neural correlate of pediatric ADHD hyperactivity-impulsivity symptoms.Frontiers in psychiatry · 2026Article
- Abnormal inter-hemispheric functional cooperation in blepharospasm.Frontiers in neurology · 2025Article
- Sex differences in brain functional specialization and interhemispheric cooperation among children with autism spectrum disorders.Scientific reports · 2024Article
- Article
- Brain functional specialization and cooperation in Alzheimer's disease.Brain and behavior · 2024Article
- Parsing Brain Network Specialization: A Replication and Expansion of Wang et al. (2014).bioRxiv : the preprint server for biology · 2024Article
- Evidence for a Compensatory Relationship between Left- and Right-Lateralized Brain Networks.bioRxiv : the preprint server for biology · 2023Article
- Altered Coupling Between Cerebral Blood Flow and Voxel-Mirrored Homotopic Connectivity Affects Stroke-Induced Speech Comprehension Deficits.Frontiers in aging neuroscience · 2022Article
- Abnormal interhemispheric functional cooperation in schizophrenia follows the neurotransmitter profiles.Journal of psychiatry & neuroscience : JPNArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Cerebral specialization and inter-hemispheric cooperation are two of the most prominent functional architectures of the human brain. Their dysfunctions may be related to pathophysiological changes in patients with Parkinson's disease (PD), who are characterized by unbalanced onset and progression of motor symptoms. This study aimed to characterize the two intrinsic architectures of hemispheric functions in PD using resting-state functional magnetic resonance imaging. Seventy idiopathic PD patients and 70 age-, sex-, and education-matched healthy subjects were recruited. All participants underwent magnetic resonance image scanning and clinical evaluations. The cerebral specialization (Autonomy index, AI) and inter-hemispheric cooperation (Connectivity between Functionally Homotopic voxels, CFH) were calculated and compared between groups. Compared with healthy controls, PD patients showed stronger AI in the left angular gyrus. Specifically, this difference in specialization resulted from increased functional connectivity (FC) of the ipsilateral areas (e.g., the left prefrontal area), and decreased FC in the contralateral area (e.g., the right supramarginal gyrus). Imaging-cognitive correlation analysis indicated that these connectivity were positively related to the score of Montreal Cognitive Assessment in PD patients. CFH between the bilateral sensorimotor regions was significantly decreased in PD patients compared with controls. No significant correlation between CFH and cognitive scores was found in PD patients. This study illustrated a strong leftward specialization but weak inter-hemispheric coordination in PD patients. It provided new insights to further clarify the pathological mechanism of PD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.