Evidence map›Paper›PMID 34427674›Full record

ReviewJournal of industrial microbiology & biotechnology2021

Challenges in the production and use of probiotics as therapeuticals in cancer treatment or prevention.

Alejandra Mejía-Caballero, Vianey Anahi Salas-Villagrán, Alaide Jiménez-Serna, Amelia Farrés

Abstract readReview
In one paragraph

Review in Journal of industrial microbiology & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Application and Challenges of Using ProbioticDiseases (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alejandra Mejía-CaballeroDepartamento de Ingeniería Celular y Biocatálisis, Insituto de Biotecnología, Universidad Nacional Autónoma de México, 62210 Cuernavaca, Morelos, México.
Vianey Anahi Salas-VillagránDepartamento de Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de México, 04510 Ciudad de México, México.
Alaide Jiménez-SernaCentro de Investigación y Capacitación en Gastronomía, Universidad del Claustro de Sor Juana, 06080 Ciudad de México, México.
Amelia FarrésDepartamento de Alimentos y Biotecnología, Facultad de Química, Universidad Nacional Autónoma de México, 04510 Ciudad de México, México.ORCID 0000-0003-3517-6447

Funding

CONACYTUNAM
6 · The paper itself

Abstract

Probiotics were defined as microbial strains that confer health benefits to their consumers. The concept has evolved during the last 20 years, and today metabolites produced by the strains, known as postbiotics, and even dead cells, known as paraprobiotics, are closely associated to them. The isolation of commensal strains from human microbiome has led to the development of next generation probiotics. This review aims to present an overview of the developments in the area of cancer prevention and treatment, intimately related to advances in the knowledge of the microbiome role in its genesis and therapy. Strain identification and characterization, production processes, delivery strategies, and clinical evaluation are crucial to translate results into the market with solid scientific support. Examples of recent tools in isolation, strain typification, quality control, and development of new probiotic strains are described. Probiotics market and regulation were originally developed in the food sector, but these new strategies will impact the pharmaceutical and health sectors, requiring new considerations in regulatory frameworks.

Indexed as

NeoplasmsProbioticsHumansCancerClinical trialsMicrobiomePostbioticsProbiotics

Identifiers

PMID34427674
PMCPMC8867594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.