ArticleThe Plant cell2021
The CRY2-COP1-HY5-BBX7/8 module regulates blue light-dependent cold acclimation in Arabidopsis.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Precise scheduling of B-box transcription factors: the core network for balancing plant growth, metabolism and stress resistance.Frontiers in plant science · 2026Pooled it
- MAC5A dual-functionally regulates cold responses at both transcriptional and post-transcriptional levels.Journal of advanced research · 2026Article
- SlBBX19 modulates plant development and negatively regulates chilling tolerance in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Light Regulation of Anthocyanin Biosynthesis in Plants: From Mechanisms to Applications.Plant, cell & environment · 2026Review
- Physiological and transcriptomic analyses reveal HuBBX1 activating the transcription of COR genes to enhance pitaya cold tolerance.Plant cell reports · 2026Article
- Overexpression of ArabidopsisPlant biotechnology (Tokyo, Japan) · 2026Article
- Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience.The New phytologist · 2026Review
- Plant responses to cold stress: molecular and physiological adaptive mechanisms with breeding advances.Frontiers in plant science · 2026Review
- Convergence between light quality and methyl jasmonate signaling in the regulation of betalain biosynthesis.Frontiers in plant science · 2026Review
- Blue-enriched LED light modulates biochemical and proteomic traits without affecting yield in indoor-grown cress microgreens.Frontiers in plant science · 2026Article
- Post-translational modifications play indispensable roles in cold stress responses of plants.Frontiers in plant science · 2026Review
- Elucidating the effects of blue light and NaCl on flavonoid biosynthesis in detachedFood chemistry: X · 2026Article
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- Genome-wide characterization of ZmCRY genes: unveiling stress response mechanisms and the role of ZmCRYPHR2 in salinity tolerance.BMC plant biology · 2025Article
- Natural variation of GNP2 enhances grain number to benefit rice yield.Nature communications · 2025Article
- Identification and Expression Characteristics of the Cryptochrome Gene Family inPlants (Basel, Switzerland) · 2025Article
- Complex Signaling Networks Underlying Blue-Light-Mediated Floral Transition in Plants.Plants (Basel, Switzerland) · 2025Review
- Genome-Wide Identification ofInternational journal of molecular sciences · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light and temperature are two key environmental factors that coordinately regulate plant growth and development. Although the mechanisms that integrate signaling mediated by cold and red light have been unraveled, the roles of the blue light photoreceptors cryptochromes in plant responses to cold remain unclear. In this study, we demonstrate that the CRYPTOCHROME2 (CRY2)-COP1-HY5-BBX7/8 module regulates blue light-dependent cold acclimation in Arabidopsis thaliana. We show that phosphorylated forms of CRY2 induced by blue light are stabilized by cold stress and that cold-stabilized CRY2 competes with the transcription factor HY5 to attenuate the HY5-COP1 interaction, thereby allowing HY5 to accumulate at cold temperatures. Furthermore, our data demonstrate that B-BOX DOMAIN PROTEIN7 (BBX7) and BBX8 function as direct HY5 targets that positively regulate freezing tolerance by modulating the expression of a set of cold-responsive genes, which mainly occurs independently of the C-repeat-binding factor pathway. Our study uncovers a mechanistic framework by which CRY2-mediated blue-light signaling enhances freezing tolerance, shedding light on the molecular mechanisms underlying the crosstalk between cold and light signaling pathways in plants.
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