ArticleThe Journal of cell biology2021
Intracellular wetting mediates contacts between liquid compartments and membrane-bound organelles.
Article in The Journal of cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Droplets sitting on thin elastic sheets: a study with the boundary element method.The European physical journal. E, Soft matter · 2026Article
- The Primary Cilium: A New Player in Muscle Stem Cell Biology.Stem cell reviews and reports · 2026Review
- A practical guide to investigating biomolecular condensates: a comment from the plant community.Science China. Life sciences · 2026Review
- What is active wetting?The European physical journal. E, Soft matter · 2026Review
- Plasma membrane invaginations and their diverse cellular functions.BMC biology · 2026Review
- Physiological implications of phase separation in vesicle organization and trafficking.BMC biology · 2026Review
- Condensate-mediated shape transformations of cellular membranes by capillary forces.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanochemical feedback between confinement and actin crosslinking drives the shape dynamics of liquid-like droplets.Nature communications · 2026Article
- Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked CabioRxiv : the preprint server for biology · 2026Article
- Biomolecular condensates as cellular memory modules: Thermodynamic principles and plant stress adaptation.Biophysical journal · 2026Review
- Polymer-Wrapped Oil Droplets and Polymer Particles with Complex Curvilinear Polyhedral Geometries by Surfactant-Driven Elastocapillary Buckling of Polymer Capsules.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Designing Tunable DNA Condensates to Control Membrane Budding Transformation in Synthetic Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Organizing principles underlying COPII-mediated transport.Current opinion in cell biology · 2025Review
- Chemically active wetting.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Lipid packing and cholesterol content regulate membrane wetting and remodeling by biomolecular condensates.Nature communications · 2025Article
- Vimentin undergoes liquid-liquid phase separation to form droplets which wet and stabilize actin fibers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Are redox catalytic reaction rates accelerated in microdroplets on electrode surfaces?Journal of solid state electrochemistry : current research and development in science and technology · 2025Article
- Autophagy adaptors mediate Parkin-dependent mitophagy by forming sheet-like liquid condensates.The EMBO journal · 2024Article
- Basic design of artificial membrane-less organelles using condensation-prone proteins in plant cells.Communications biology · 2024Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein-rich droplets, such as stress granules, P-bodies, and the nucleolus, perform diverse and specialized cellular functions. Recent evidence has shown the droplets, which are also known as biomolecular condensates or membrane-less compartments, form by phase separation. Many droplets also contact membrane-bound organelles, thereby functioning in development, intracellular degradation, and organization. These underappreciated interactions have major implications for our fundamental understanding of cells. Starting with a brief introduction to wetting phenomena, we summarize recent progress in the emerging field of droplet-membrane contact. We describe the physical mechanism of droplet-membrane interactions, discuss how these interactions remodel droplets and membranes, and introduce "membrane scaffolding" by liquids as a novel reshaping mechanism, thereby demonstrating that droplet-membrane interactions are elastic wetting phenomena. "Membrane-less" and "membrane-bound" condensates likely represent distinct wetting states that together link phase separation with mechanosensitivity and explain key structures observed during embryogenesis, during autophagy, and at synapses. We therefore contend that droplet wetting on membranes provides a robust and intricate means of intracellular organization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.