Evidence map›Paper›PMID 34427600›Full record

Observational studyJAMA2021

Trends in Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in the US, 2001-2017.

Jean M Lawrence, Jasmin Divers, Scott Isom, Sharon Saydah, Giuseppina Imperatore, Catherine Pihoker, Santica M Marcovina, Elizabeth J Mayer-Davis, Richard F Hamman, Lawrence Dolan and 4 more

Erratum issued 3 registry-linked trialsOpen access · greenAbstract readObservational Study
In one paragraph

Observational study in JAMA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 376 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 6 pooled it
72.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06067451 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Impact of SMART GOAL Setting Protocol on Body Weight and Metabolic Parameters in Children and Adolescents With Prediabetes; a Randomized Clinical Trial.

TypeinterventionalSponsorNorthwell HealthRan2023 to 2025Enrolled80ConditionsPreDiabetes, Adolescent Obesity, Behavior, Health, Nutritional and Metabolic DiseasesArmsSMART GOALS Setting Tool/ Protocol
NCT06080425 nacompletednot on this mapstarted 2023, after this paper: background citation

Addressing Intergenerational Obesity and Promoting Healthy Eating and Physical Activity Among Individuals [PIHRK'D] Living With Diabetes in Rural Kentucky

TypeinterventionalSponsorThe University of Texas Medical Branch, GalvestonRan2023 to 2026Enrolled48ConditionsDiabetes Mellitus, Type 2ArmsMedical Nutrition Therapy
NCT06837181 recruitingnot on this mapstarted 2025, after this paper: background citation

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

TypeobservationalSponsorJaeb Center for Health ResearchRan2025 to 2028Enrolled200ConditionsCystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, RetinopathyArmsobservational study
3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 6 syntheses or guidelines pooled it, 586 citations in OpenAlex.

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316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 1 country.

Jean M LawrenceDivision of Epidemiologic Research, Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena.
Jasmin DiversDivision of Health Services Research, Department of Foundations of Medicine, New York University Langone School of Medicine, Mineola.
Scott IsomDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina.
Sharon SaydahDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Hyattsville, Maryland.
Giuseppina ImperatoreDivision of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle.
Santica M MarcovinaDivision of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle.
Elizabeth J Mayer-DavisDepartments of Nutrition and Medicine, University of North Carolina at Chapel Hill.
Richard F HammanDepartment of Epidemiology, Colorado School of Public Health, Anschutz Medical Campus, Aurora.
Lawrence DolanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, Anschutz Medical Campus, Aurora.
David J PettittSanta Barbara, California.
Angela D LieseDepartment of Epidemiology and Biostatistics, University of South Carolina Arnold School of Public Health, Columbia.
SEARCH for Diabetes in Youth Study Group
University of Washington · USCenters for Disease Control and Prevention · USColorado School of Public Health · USNational Center for Chronic Disease Prevention and Health Promotion · USNational Institutes of Health · USNew York University · USUniversity of Cincinnati · USUniversity of Colorado Denver · USUniversity of North Carolina at Chapel Hill · USUniversity of South Carolina · USWake Forest University · US

Funding

Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
Limited Competition for the Continuation of the SEARCH for Diabetes in Youth Cohort Study (UC4)SEARCH for Diabetes in Youth Cohort StudyUC4DK108173 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B. · 2015 to 2016
$14.8M
UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HUTTON, JOHN C · 2000 to 2010
$14.0M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
Population-based Diabetes Youth RegistryU18DP006131 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WAGENKNECHT, LYNNE E · 2015 to 2019
$3.8M
SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina CenterU18DP002708 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2010 to 2014
$3.6M
SEARCH for Diabetes in Youth 2: South Carolina CenterU01DP000254 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2005 to 2009
$3.5M
SEARCH for Diabetes in Youth 2: Washington SiteU01DP000244 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2005 to 2009
$2.7M
Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort StudyR01DK127208 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DAGOSTINO, RALPH B., JENSEN, ELIZABETH T · 2020 to 2020
$2.0M
NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NHLBI NIH HHS K23 HL148394NHLBI NIH HHS L40 HL148910NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R01 DK127208NIDDK NIH HHS UC4 DK108173
6 · The paper itself

Abstract

Importance: Changes in the prevalence of youth-onset diabetes have previously been observed. Objective: To estimate changes in prevalence of type 1 and type 2 diabetes in youths in the US from 2001 to 2017. Design, Setting, and Participants: In this cross-sectional observational study, individuals younger than 20 years with physician-diagnosed diabetes were enumerated from 6 areas in the US (4 geographic areas, 1 health plan, and select American Indian reservations) for 2001, 2009, and 2017. Exposures: Calendar year. Main Outcomes and Measures: Estimated prevalence of physician-diagnosed type 1 and type 2 diabetes overall and by race and ethnicity, age, and sex. Results: Among youths 19 years or younger, 4958 of 3.35 million had type 1 diabetes in 2001, 6672 of 3.46 million had type 1 diabetes in 2009, and 7759 of 3.61 million had type 1 diabetes in 2017; among those aged 10 to 19 years, 588 of 1.73 million had type 2 diabetes in 2001, 814 of 1.85 million had type 2 diabetes in 2009, and 1230 of 1.85 million had type 2 diabetes in 2017. The estimated type 1 diabetes prevalence per 1000 youths for those 19 years or younger increased significantly from 1.48 (95% CI, 1.44-1.52) in 2001 to 1.93 (95% CI, 1.88-1.98) in 2009 to 2.15 (95% CI, 2.10-2.20) in 2017, an absolute increase of 0.67 per 1000 youths (95%, CI, 0.64-0.70) and a 45.1% (95% CI, 40.0%-50.4%) relative increase over 16 years. The greatest absolute increases were observed among non-Hispanic White (0.93 per 1000 youths [95% CI, 0.88-0.98]) and non-Hispanic Black (0.89 per 1000 youths [95% CI, 0.88-0.98]) youths. The estimated type 2 diabetes prevalence per 1000 youths aged 10 to 19 years increased significantly from 0.34 (95% CI, 0.31-0.37) in 2001 to 0.46 (95% CI, 0.43-0.49) in 2009 to 0.67 (95% CI, 0.63-0.70) in 2017, an absolute increase of 0.32 per 1000 youths (95% CI, 0.30-0.35) and a 95.3% (95% CI, 77.0%-115.4%) relative increase over 16 years. The greatest absolute increases were observed among non-Hispanic Black (0.85 per 1000 youths [95% CI, 0.74-0.97]) and Hispanic (0.57 per 1000 youths [95% CI, 0.51-0.64]) youths. Conclusions and Relevance: In 6 areas of the US from 2001 to 2017, the estimated prevalence of diabetes among children and adolescents increased for both type 1 and type 2 diabetes.

Indexed as

AdolescentChildChild, PreschoolCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansMalePrevalenceUnited StatesYoung Adult

Identifiers

PMID34427600
PMCPMC8385600
OpenAlexW3195466285

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.