Evidence map›Paper›PMID 34427522›Full record

ArticlemSystems2021

Serine Metabolism Tunes Immune Responses To Promote

Dai-Xiao Yang, Man-Jun Yang, Yue Yin, Tian-Shun Kou, Liao-Tian Peng, Zhuang-Gui Chen, Jun Zheng, Bo Peng

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

  1. Physiological Responses in the Hepatopancreas ofAntioxidants (Basel, Switzerland) · 2026
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  5. Gene dependence during mammalianMicrobial genomics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Dai-Xiao YangCenter for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Man-Jun YangCenter for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Yue YinCenter for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Tian-Shun KouCenter for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Liao-Tian PengCenter for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Zhuang-Gui ChenDepartment of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen Universitygrid.12981.33, Guangzhou, China.
Jun ZhengFaculty of Health Sciences, University of Macaugrid.437123.0, Macau SAR, China.
Bo PengCenter for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Key Laboratory of Pharmaceutical Functional Genes, School of Life Sciences, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen Universitygrid.12981.33, Guangzhou, People's Republic of China.
Sun Yat-sen University · CNUniversity of Macau · MO

Funding

Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory 311020006National Natural Science Foundation of China (NSFC) 31822058Youth Talent Support Program of Guangdong Province 2017GC010617
6 · The paper itself

Abstract

Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are still to be explored. In this study, we find that Nile tilapia,

Indexed as

glutathionemetabolomicsoveractive immune responsereactive oxygen speciesserine

Identifiers

PMID34427522
PMCPMC8407201
OpenAlexW3196245281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.