Evidence map›Paper›PMID 34427519›Full record

ArticlemSystems2021

Uncovering Divergence in Gene Expression Regulation in the Adaptation of Yeast to Nitrogen Scarcity.

Carlos A Villarroel, Macarena Bastías, Paulo Canessa, Francisco A Cubillos

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Co-culture dynamics betweenCurrent research in food science · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Carlos A VillarroelANID, Programa Iniciativa Científica Milenio, Instituto Milenio de Biología Integrativa (iBio), Santiago, Chile.
Macarena BastíasCentro de Biotecnología Vegetal, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.
Paulo CanessaANID, Programa Iniciativa Científica Milenio, Instituto Milenio de Biología Integrativa (iBio), Santiago, Chile.
Francisco A CubillosANID, Programa Iniciativa Científica Milenio, Instituto Milenio de Biología Integrativa (iBio), Santiago, Chile.
Universidad Andrés Bello · CLUniversidad de Santiago de Chile · CL

Funding

ANID - Programa Iniciativa Cientifica Milenio ICN17_022MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1180161MINEDUC | CONICYT | Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 3170404
6 · The paper itself

Abstract

Saccharomyces cerevisiae rewires its transcriptional output to survive stressful environments, such as nitrogen scarcity under fermentative conditions. Although divergence in nitrogen metabolism among natural yeast populations has been reported, the impact of regulatory genetic variants modulating gene expression and nitrogen consumption remains to be investigated. Here, we employed an F1 hybrid from two contrasting S. cerevisiae strains, providing a controlled genetic environment to map

Indexed as

allele-specificATAC-seqfermentationgene regulationgeneticsnatural variationnitrogenregulatory divergencewineyeast

Identifiers

PMID34427519
PMCPMC8407396
OpenAlexW3153267956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.