ArticlemSystems2021
Multilevel Genome Typing Describes Short- and Long-Term Vibrio cholerae Molecular Epidemiology.
Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- An integrated genomic framework forMicrobial genomics · 2026Article
- Genome-wide investigation of outbreak-associatedFrontiers in microbiology · 2026Article
- Prevalence, Virulence and Antimicrobial Resistance ofFoods (Basel, Switzerland) · 2025Article
- CharacterizingmSystems · 2025Article
- Genomic evidence of two-staged transmission of the early seventh cholera pandemic.Nature communications · 2024Article
- Uncovering the boundaries ofmSystems · 2024Article
- Emergence and genomic insights of non-pandemic O1Microbiology spectrum · 2023Article
- Genomic epidemiology and multilevel genome typing ofEmerging microbes & infections · 2023Article
- InactivatedJournal of microbiology and biotechnology · 2022Article
- MGTdb: a web service and database for studying the global and local genomic epidemiology of bacterial pathogens.Database : the journal of biological databases and curation · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 1817, cholera, caused by Vibrio cholerae, has been characterized by seven distinct pandemics. The ongoing seventh pandemic (7P) began in 1961. In this study, we developed a Multilevel Genome Typing (MGT) tool for classifying the V. cholerae species with a focus on the 7P. MGT is based on multilocus sequence typing (MLST), but the concept has been expanded to include a series of MLST schemes that compare population structure from broad to fine resolutions. The V. cholerae MGT consists of eight levels, with the lowest, MGT1, composed of 7 loci and the highest, MGT8, consisting of the 7P core genome (3,759 loci). We used MGT to analyze 5,771 V. cholerae genomes. The genetic relationships revealed by lower MGT levels recapitulated previous findings of large-scale 7P transmission across the globe. Furthermore, the higher MGT levels provided an increased discriminatory power to differentiate subgroups within a national outbreak. Additionally, we demonstrated the usefulness of MGT for non-7P classification. In a large non-7P MGT1 type, MGT2 and MGT3 described continental and regional distributions, respectively. Finally, MGT described trends of 7P in virulence, and MGT2 to MGT3 sequence types (STs) grouped isolates of the same
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