Evidence map›Paper›PMID 34427471›Full record

ArticleInternational journal of stroke : official journal of the International Stroke Society2022

Idiopathic primary intraventricular hemorrhage and cerebral small vessel disease.

Alvin S Das, Robert W Regenhardt, Elif Gokcal, Mitchell J Horn, Nader Daoud, Kristin M Schwab, Natalia S Rost, Anand Viswanathan, W Taylor Kimberly, Joshua N Goldstein and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of stroke : official journal of the International Stroke Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  4. Hypertension control after intracerebral hemorrhage among varying small vessel disease etiologies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Alvin S DasDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2313-977X
Robert W RegenhardtDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2958-3484
Elif GokcalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Mitchell J HornDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nader DaoudDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kristin M SchwabDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Natalia S RostDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Anand ViswanathanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
W Taylor KimberlyDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Joshua N GoldsteinDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alessandro BiffiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lee H SchwammDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jonathan RosandDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Steven M GreenbergDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
M Edip GurolDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2169-4457
Harvard University · US

Funding

Vascular Dysfunction in Cerebral Amyloid AngiopathyR01AG026484 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GREENBERG, STEVEN M · 2005 to 2019
$7.5M
CEREBRAL AMYLOID ANGIOPATHY AND MECHANISMS OF BRAIN AMYLOID ACCUMULATIONR01NS096730 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BACSKAI, BRIAN J, GREENBERG, STEVEN M · 2016 to 2020
$5.7M
Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyR01NS114526 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2020 to 2024
$4.4M
Molecular Neuroimaging of Disease Mechanisms in Cerebral Amyloid AngiopathyK23NS083711 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2014 to 2018
$988k
NIA NIH HHS R01 AG026484NINDS NIH HHS K23 NS083711NINDS NIH HHS R01 NS096730NINDS NIH HHS R01 NS114526
6 · The paper itself

Abstract

backgroundAlthough primary intraventricular hemorrhage is frequently due to trauma or vascular lesions, the etiology of idiopathic primary intraventricular hemorrhage (IP-IVH) is not defined.

aimsHerein, we test the hypothesis that cerebral small vessel diseases (cSVD) including hypertensive cSVD (HTN-cSVD) and cerebral amyloid angiopathy are associated with IP-IVH.

methodsBrain magnetic resonance imaging from consecutive patients (January 2011 to September 2019) with non-traumatic intracerebral hemorrhage from a single referral center were reviewed for the presence of HTN-cSVD (defined by strictly deep or mixed-location intracerebral hemorrhage/cerebral microbleeds) and cerebral amyloid angiopathy (applying modified Boston criteria).

resultsForty-six (4%) out of 1276 patients were identified as having IP-IVH. Among these, the mean age was 74.4 ± 12.2 years and 18 (39%) were females. Forty (87%) had hypertension, and the mean initial blood pressure was 169.2 ± 40.4/88.8 ± 22.2 mmHg. Of the 35 (76%) patients who received a brain magnetic resonance imaging, two (6%) fulfilled the modified Boston criteria for possible cerebral amyloid angiopathy and 10 (29%) for probable cerebral amyloid angiopathy. Probable cerebral amyloid angiopathy was found at a similar frequency when comparing IP-IVH patients to the remaining patients with primary intraparenchymal hemorrhage (P-IPH) (27%,

conclusionsAmong IP-IVH patients, cerebral amyloid angiopathy was found in approximately one-third of patients, whereas HTN-cSVD was detected in 23%-both similar rates to P-IPH patients. Our results suggest that both cSVD subtypes may be associated with IP-IVH.

Indexed as

Cerebral Amyloid AngiopathyCerebral Small Vessel DiseasesStrokeAgedAged, 80 and overCerebral HemorrhageFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedcerebral amyloid angiopathyCerebral hemorrhagecerebral small vessel diseases

Identifiers

PMID34427471
PMCPMC10947797
OpenAlexW3193545108

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.