Evidence map›Paper›PMID 34427390›Full record

ArticleAngewandte Chemie (International ed. in English)2021

A New Dioxazolone for the Synthesis of 1,2-Aminoalcohols via Iridium(III)-Catalyzed C(sp

Kevin Antien, Andrea Geraci, Michael Parmentier, Olivier Baudoin

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kevin AntienUniversity of Basel, Department of Chemistry, St. Johanns-Ring 19, 4056, Basel, Switzerland.ORCID 0000-0003-0558-2532
Andrea GeraciUniversity of Basel, Department of Chemistry, St. Johanns-Ring 19, 4056, Basel, Switzerland.ORCID 0000-0001-7630-2580
Michael ParmentierNovartis Pharma AG, Chemical & Analytical Development, 4056, Basel, Switzerland.ORCID 0000-0002-1732-9641
Olivier BaudoinUniversity of Basel, Department of Chemistry, St. Johanns-Ring 19, 4056, Basel, Switzerland.ORCID 0000-0002-0847-8493
University of Basel · CHNovartis (Switzerland) · CH

Funding

novartisuniversität basel
6 · The paper itself

Abstract

Vicinal aminoalcohols are widespread structural motifs in bioactive molecules. We report the development of a new dioxazolone reagent containing a p-nitrophenyldifluoromethyl group, which 1. displays a good safety profile; 2. shows a remarkably high reactivity in the oxime-directed iridium(III)-catalyzed amidation of unactivated C(sp

Indexed as

1,2-amino alcoholamidationC−H activationdioxazoloneiridium

Identifiers

PMID34427390
PMCPMC8519009
OpenAlexW3194770850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.