ArticleVeterinary and comparative oncology2021
Diagnostic accuracy of optical coherence tomography for surgical margin assessment of feline injection-site sarcoma.
Article in Veterinary and comparative oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Raman spectral band imaging for the diagnostics and classification of canine and feline cutaneous tumors.The veterinary quarterly · 2025Article
- Machine learning based diagnostics of veterinary cancer on ultrasound and optical imaging data.The veterinary quarterly · 2025Article
- Polarisation Sensitive Optical Coherence Tomography Image Characteristics for Gastrointestinal Tumours and Normal Tissues at Surgical Margins in Dogs.Veterinary and comparative oncology · 2025Article
- Differentiation of canine and feline neoplasms using multi-modal imaging and machine learning.Scientific reports · 2025Article
- Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumours.Veterinary and comparative oncology · 2022Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 1 country.
Funding
Abstract
The invasive, locally aggressive nature of feline injection-site sarcomas (FISSs) poses a unique challenge for surgeons to obtain complete margins with surgical excision. Optical coherence tomography (OCT), an imaging technology that uses light waves to generate real-time views of tissue architecture, provides an emerging solution to this dilemma by allowing fast, high-resolution scanning of surgical margins. The purpose of this study was to use OCT to assess surgical margins of FISS and to evaluate the diagnostic accuracy of OCT for detecting residual cancer using six evaluators of varying experience. Five FISSs were imaged with OCT to create a training set of OCT images that were compared with histopathology. Next, 25 FISSs were imaged with OCT prior to histopathology. Six evaluators of varying experience participated in a training session on OCT imaging after which each of the evaluators was given a dataset that included OCT images and videos to score on a scale from cancerous to non-cancerous. Diagnostic accuracy statistics were calculated. The overall sensitivity and specificity for classification of OCT images by evaluators were 78.9% and 77.6%, respectively. Correct classification rate of OCT images was associated with experience, while individual sensitivities and specificities had more variation between experience groups. This study demonstrates the ability of evaluators to correctly classify OCT images with overall low levels of experience and training and also illustrates areas where increased training can improve accuracy of evaluators in interpretation of OCT surgical margin images.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.