ArticleDevelopment (Cambridge, England)2021
Intrinsic positional memory guides target-specific axon regeneration in the zebrafish vagus nerve.
Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization.Development (Cambridge, England) · 2026Article
- Human vagus nerve fascicular anatomy and its implications for targeted cardiac stimulation: a microCT segmentation and histological pilot anatomical study.Frontiers in neuroscience · 2026Article
- Review
- Modeling traumatic brain and neural injuries: insights from zebrafish.Frontiers in molecular neuroscience · 2025Review
- The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025Review
- Position-independent functional refinement within the vagus motor topographic map.Cell reports · 2024Article
- High-resolution Cell Transplantation in Embryonic and Larval Zebrafish.Journal of visualized experiments : JoVE · 2024Article
- Position-independent functional refinement within the vagus motor topographic map.bioRxiv : the preprint server for biology · 2024Article
- Development and regeneration of the vagus nerve.Seminars in cell & developmental biology · 2024Review
- Article
- Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus.PLoS biology · 2023Article
- Neuronal birthdate reveals topography in a vestibular brainstem circuit for gaze stabilization.Current biology : CB · 2023Article
- A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration.bioRxiv : the preprint server for biology · 2023Article
- Organotopic organization of the porcine mid-cervical vagus nerve.Frontiers in neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regeneration after peripheral nerve damage requires that axons re-grow to the correct target tissues in a process called target-specific regeneration. Although much is known about the mechanisms that promote axon re-growth, re-growing axons often fail to reach the correct targets, resulting in impaired nerve function. We know very little about how axons achieve target-specific regeneration, particularly in branched nerves that require distinct targeting decisions at branch points. The zebrafish vagus motor nerve is a branched nerve with a well-defined topographic organization. Here, we track regeneration of individual vagus axons after whole-nerve laser severing and find a robust capacity for target-specific, functional re-growth. We then develop a new single-cell chimera injury model for precise manipulation of axon-environment interactions and find that (1) the guidance mechanism used during regeneration is distinct from the nerve's developmental guidance mechanism, (2) target selection is specified by neurons' intrinsic memory of their position within the brain, and (3) targeting to a branch requires its pre-existing innervation. This work establishes the zebrafish vagus nerve as a tractable regeneration model and reveals the mechanistic basis of target-specific regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.