ArticleIndian journal of ophthalmology2021
Evaluating the presence of SARS-CoV-2 in the intraocular fluid of COVID-19 patients.
Article in Indian journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Acute angle-closure glaucoma before, during, and after the outbreak of COVID-19 in China.Heliyon · 2024Article
- Review
- Considerations of COVID-19 in Ophthalmology.Microorganisms · 2023Review
- Molecular Diagnosis of COVID-19; Biosafety and Pre-analytical Recommendations.Iranian journal of pathology · 2023Review
- The Outbreak of Acute Primary Angle-Closure Cases During the COVID-19 Omicron Variant Pandemic at a Tertiary Eye Center in Shanghai.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Response to comments on: Evaluating the presence of SARS-CoV-2 in the intraocular fluid of COVID-19 patients.Indian journal of ophthalmology · 2022Article
- Severe acute respiratory syndrome Corona virus and intraocular fluid sampling.Indian journal of ophthalmology · 2021Article
- Does ocular tissue contain SARS CoV-2?Indian journal of ophthalmology · 2021Article
- Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review.Oman journal of ophthalmologyReview
- COVID-19 and ocular complications: A review of ocular manifestations, diagnostic tools, and prevention strategies.Advances in ophthalmology practice and researchReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo detect the presence of SARS-CoV-2 in aqueous and vitreous humor of COVID-19 patients in a pilot study.
methods: Consecutive patients planned for emergency ophthalmic surgeries after ocular trauma were subjected to naso-oropharyngeal RT-PCR test for SARS-CoV-2. Laboratory-confirmed cases were enrolled for the study. During surgery, 0.1 mL aqueous and vitreous each was aspirated. The vitreous tap was collected on clinical suspicion of endophthalmitis. RT-PCR test was used to detect SARS-COV-2 nucleotide in the samples. Cycle threshold (Ct) for E gene of ≤35 along with confirmatory results on one of the two target genes (RdRp or ORF1b) was considered as positive.
results: One hundred and thirty two patients were found positive on naso-oropharyngeal RT-PCR test for SARS-CoV-2 preoperatively. Seven patients with ocular trauma were studied. The mean age was 31.8 years. There were six male and one female patient. Two patients had symptoms of mild COVID-19 disease and the rest were asymptomatic. The mean Ct value of the E gene on naso-oropharyngeal RT-PCR was 23.14 ± 4.7. Corneal and corneoscleral laceration repair was done in five patients, intracorneal wooden foreign body was removed in one patient, and injection of intravitreal antibiotics was done in one patient. Aqueous and vitreous tap was collected in 7 and 5 patients, respectively. None of the aqueous or vitreous samples was found positive for SARS-CoV-2.
conclusion: SARS-CoV-2 was not detected by RT-PCR in aqueous or vitreous humor in this pilot study. Future studies with a larger sample size are needed to further explore the presence of SARS-CoV-2 in intraocular fluids.
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